Method of producing macrolide compound

Details Method of producing macrolide compound Method of producing macrolide compound

Filed on

2003-11-27

Date issued

2010-06-29

Examiner

Mondesi, Robert (Department: 1645)

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Micro-organism, per se ; compositions thereof; proces of...

SubSubClass

Bacteria or actinomycetales; media therefor

Other Related Categories

C514S450000

Type

Reexamination Certificate

Status

active

Patent number

07745198

Description

ABSTRACT:
The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genusMortierella, the genusStreptomycesor the family Micromonosporaceae (for example,Streptomycessp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured myceha and oxygen, and then 11107D substance which is a target material is collected from the treating solution.

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