Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2009-06-02
2010-12-28
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S662000, C562S450000
Reexamination Certificate
active
07858665
ABSTRACT:
The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I):in-line-formulae description="In-line Formulae" end="lead"?R—NR1c—(K)k0—(B)b0—(C)c0—NO2 (I)in-line-formulae description="In-line Formulae" end="tail"?whereinc0, b0 and k0 are 0 or 1;R is the radical of an analgesic drug for chronic pain, for instance neurophatic pain;R1cis H or alkyl with from 1 to 5 carbon atoms;B is such that its precursor is selected from amino acids, hydroxy acids, polyalcohol, compounds;C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
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Gary J. Bennett, et al.; A Peripheral Mononeuropathy in Rat That Produces Disorders of Pain Sensation Like Those Seen in Man; Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, Pain, 33 (1988), pp. 87-107, Elsevier, USA.
M.W. Radomski, et al; The Anti-Aggregating Properties of Vascular Endothelium: Interactions Between Prostacyclin and Nitric Oxide, The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, The Macmillan Press Ltd 1987, pp. 640-646.
James E. F. Reynolds, et al.; Martindale the Extra Pharmacopoeia, Thirtieth Edition, The Pharmaceutical Press, London, 1993 p. 374.
Almirante Nicoletta
Del Soldato Piero
Ongini Ennio
Anderson Rebecca L
Arent & Fox LLP
Nicox S.A.
Young Shawquia
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