Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-12-13
2010-02-16
Raghu, Ganapathirama (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S232000, C435S183000, C435S069100, C536S023200, C536S023700
Reexamination Certificate
active
07662604
ABSTRACT:
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
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Bosques Carlos
Capila Ishan
Pojasek Kevin
Prabhakar Vikas
Raman Rahul
Massachusetts Institute of Technology
Raghu Ganapathirama
Wolf Greenfield & Sacks P.C.
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