Polynucleotide intercalator interceptors and inhibitors

Details Polynucleotide intercalator interceptors and inhibitors Polynucleotide intercalator interceptors and inhibitors

2001-12-06

2010-02-16

Riley, Jezia (Department: 1637)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C514S025000, C514S04400A, C424S001110, C424S001650, C435S174000

Reexamination Certificate

active

07662767

ABSTRACT:
A method of using modified xanthine molecules as a binding agent is disclosed. Xanthine molecules with at least one substitution of a methyl group at the N1, N3, N7, or N9 position bind to intercalating molecules efficiently. This method can be applied to inhibiting intercalating molecules from binding to nucleic acids, as well as removing intercalating molecules that have been bound to nucleic acids. This method can also be applied to synthesize an efficient drug delivery system for compounds that have low solubility in aqueous media, including anti-neoplastic agents. The method can also be applied to flurosecently labeling nucleic acids.

REFERENCES:
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Bedner, E. et al., “Caffeine Dissociates Comlexes between DNA and Intercalating Dyes: Appliaiton for Bleaching Fluorochrome-stained Cells for Their Subsequent Restaining and Analysis by Laser Scanning Cytometry”, Abstract,Cytometry: The Journal of the Society of Analytical Cytology, vol. 43, No. 1, XP-002226113, Jan. 1, 2001.
Lyles, Mark B., et al., “Caffeine and Other Xanthines as Interceptors and Scavengers of Planar Polyaromatic DNA Intercalators”, Proceedings of the American Association for Cancer Research Annual Meeting, No. 41, p. 662, XP-02226111, Mar. 2000.

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