Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-01-07
2010-02-02
Crane, Lawrence E (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07655769
ABSTRACT:
Orthogonally protected disaccharide building blocks for synthesis of heparin saccharide are disclosed. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3and P4are different, and of them P1is an ester-type protecting group, P2is a hydroxyl protecting group that could be oxidized to a carboxylic acid, P3is a hydroxyl protecting group, and P4is a hydroxyl protecting group which allows chemoselective deprotection with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Acting as an elongation unit, the disaccharide building block of formula (I) may react with a starting unit of formula (II) to synthesize a heparin saccharide of desired size.
REFERENCES:
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Hung Shang-Cheng
Lee Jing-Chyi
Lu Xin-An
Academia Sinica
Crane Lawrence E
Intellectual Property Connections, Inc.
Saunders Hsiu-Ming
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