Stable lipid-comprising drug delivery complexes and methods...

Details Stable lipid-comprising drug delivery complexes and methods... Stable lipid-comprising drug delivery complexes and methods...

2007-11-20

2010-02-02

Schnizer, Richard (Department: 1635)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C424S450000, C514S04400A, C530S300000, C530S350000, C536S023100

Reexamination Certificate

active

07655468

ABSTRACT:
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

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