Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2003-02-28
2010-06-29
Epps-Smith, Janet L. (Department: 1633)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S022100, C536S023100, C536S025300
Reexamination Certificate
active
07745417
ABSTRACT:
The object of the present invention is to provide a nucleoside or nucleotide having an unnatural base. The nucleoside or nucleotide of the present invention has a 5-substituted-2-oxo(1H)-pyridin-3-yl group as a base. Preferably, the 5-position of the above base is substituted with a substituent selected from the group consisting of the following:1) a photoreactive group selected from iodine and bromine;2) an alkenyl group, an alkynyl group or an amino group, or a derivative thereof;3) biotin or a derivative thereof; and4) a fluorescent molecule selected from fluorescein, 6-carboxyfluorescein, tetramethyl-6-carboxyrhodamine, and derivatives thereof.
REFERENCES:
patent: 6447998 (2002-09-01), Froehler et al.
patent: 6495672 (2002-12-01), Froehler et al.
patent: 2003/0120065 (2003-06-01), Froehler et al.
patent: WO-01/16149 (2001-03-01), None
Ohtsuki et al. PNAS, Apr. 2001, vol. 98, No. 9, pp. 4922-4925.
Guo et al. Nucleic Acids Research 1998, vol. 26, No. 8, pp. 1863-1869.
Battersby et al., J. Am. Chem. Soc., vol. 121, (1999), pp. 9781-9789.
Campbell et al., Oncogene, vol. 17, (1998), pp. 1395-1413.
Chen et al., Anal. Chem., vol. 28, (1956), pp. 1756-1758.
Ellington et al., Nature, vol. 346, (1990), pp. 818-822.
Fang et al., Anal. Chem., vol. 73, (2001), pp. 5752-5757.
Fujiwara et al., Bioorg. Med. Chem. Lett. vol. 11, (2001), pp. 2221-2223.
Golden et al., Journal of Biotechnology, vol. 81, (2000), pp. 167-178.
Hirao et al., J. Biol. Chem., vol. 275, (2000), pp. 4943-4948.
Hirao et al., Chem. Lett., (2001), pp. 914-915.
Hirao et al., Nature Biotechnol., vol. 20, (2002), pp. 177-182.
Inouye et al., J. Biol. Chem., vol. 275, (2000), pp. 3737-3740.
Ishikawa et al., Tetrahedron Letters, vol. 41, (2000), pp. 3931-3034.
Jensen et al., Proc. Natl. Acad. Sci. USA, vol. 92, (1995), pp. 12220-12224.
Jhaveri et al., Nature Biotechnology, vol. 18, (2000), pp. 1293-1297.
Kolch, Biochem. J., vol. 351, (2000), pp. 289-305.
Koyama et al., FEBS Letters, vol. 380, (1996), pp. 113-117.
Latham et al., Nucleic Acids Research, vol. 22, (1994), pp. 2817-2822.
Ludwig et al., J. Org. Chem., vol. 54, (1989), pp. 631-635.
Matulic-Adamic et al., Tetrahedron Letters, vol. 38, (1997), pp. 203-206.
Meisenheimer et al., Crit. Rev. Biochem. Mol. Biol., vol. 32, (1997), pp. 101-140.
Morales et al., J. Am. Chem. Soc., vol. 121, (1999), pp. 2323-2324.
Ohtsuki et al., Proc. Natl. Acad. Sci. USA, vol. 98, (2001), pp. 4922-4925.
Piccirilli et al., Nature, vol. 343, (1990), pp. 33-37.
Piccirilli et al., Biochemistry, vol. 30, (1991), pp. 10350-10356.
Rapp et al., Cold Spring Harb. Symp. Quant. Biol., vol. 53, (1988), pp. 173-184.
Switzer et al., Biochemistry, vol. 32, (1993), pp. 10489-10496.
Tae et al., J. Am. Chem. Soc., vol. 123, (2001), pp. 7439-7440.
Wu et al., J. Am. Chem. Soc., vol. 122, (2000), pp. 7621-7632.
Yamamoto et al., Genes to Cells, vol. 5, (2000), pp. 389-396.
Broekman et al., Recueil, vol. 81, (1962), pp. 107-111.
Gott et al., Biochemistry, vol. 30, (1991), pp. 6290-6295.
Petach et al., Current Opinion in Biotechnology, vol. 13, (2002), pp. 309-314.
Brody et al., Molecular Diagnosis, vol. 4, (1999), pp. 381-388.
Theissen et al., Anal. Biochem., vol. 179, (1989), pp. 98-105.
Bellinzoni et al., Mol. Cell. Probes, Vol. 3, (1989), pp. 233-244.
Langer et al., Proc. Natl. Acad. Sci. USA, vol. 78, (1981), pp. 6633-6637.
Ruby et al., Methods in Enzymology, vol. 181, (1990), pp. 97-121.
Huang et al., RNA, vol. 9, (2003), pp. 1562-1570.
Ichiro Hirao at al., Protein, Nucleic acid and Enzyme, vol. 47, No. 14, pp. 1904 to 1913 (Nov. 2002).
I. Hirao et al., Bioorganic & Medicinal Chemistry Letters, vol. 12, pp. 1391 to 1393, (May 2002).
Silverman et al., “Molecular Moment Similarity Between Several Nucleoside Analogs of Thymidine and Thymidine”, Journal of Biomolecular Structure & Dynamics, ISSN 0739-1102, vol. 16, No. 6, pp. 1169-1175, 1999, Yorktown Heights, NY.
Hirao Ichiro
Hirao Michiko
Mitsui Tsuneo
Yokoyama Shigeyuki
Birch & Stewart Kolasch & Birch, LLP
Epps-Smith Janet L.
Japan Science and Technology Agency
RIKEN
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