Tri-branched biologically active copolymer

Details Tri-branched biologically active copolymer Tri-branched biologically active copolymer

2005-12-30

2010-10-12

Hartley, Michael G (Department: 1618)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Ion exchange resin

Reexamination Certificate

active

07811555

ABSTRACT:
The present invention discloses a tri-branched copolymer comprising a hydrophobic domain, a hydrophilic domain, a biologically active moiety, and an alkyl core of 2 to 10 carbon atoms. The hydrophobic domain, the hydrophilic domain, and the biologically active moiety are separately linked to the alkyl core of 2 to 10 carbon atoms through three functional groups, wherein said three functional groups are independently the same or different. Preferably, the tri-branched copolymer is prepared through reversible addition fragmentation transfer (RAFT) polymerization and conjugation reactions. The present invention also discloses a coating composition for applying on at least a portion of one surface of an article. The coating composition comprises the inventive tri-branched copolymer. In another aspect, the present invention discloses an article having the inventive coating composition thereon. Preferably, the article is a medical device or a component of a medical device.

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Feng, Xiao-Shuang et al: “Synthesis of Amphiphilic Miktoarm ABC Star Copolymers by RAFT Mechanism Using Maleic Anhydride as Linking Agent” Macromolecules, vol. 35, No. 13, 2002, 4888-4893.
Shi, Peng-Jie et al., “Block and star block copolymers by mechanism transformation X . . . ”European Polymer Journal, 2004, 20, 1283-1290.
www.surmodics.com.

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