Method for determining genotoxicity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120

Reexamination Certificate

active

07745152

ABSTRACT:
Methods and reagents for determining the genotoxicity of a compound based on genomic responses to contact therewith are provided.

REFERENCES:
patent: WO 99/53092 (1999-10-01), None
patent: WO 2004/037200 (2004-05-01), None
Van de Peer (2006) Heredity 96:204-205.
Smith et al. (1997) Nature Biotechnol. 15:1222-1223.
Skolnick et al. (2000) Trends Biotechnol. 18:34-39.
Khor et al. (2006) Pharm. Res. 23:1659-1664.
Collins, Francis S., “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”,Proc Natl Acad Sci, Dec. 2002, 99(26):16899-16903.
Hu, Ting, et al, “Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins”,Mutation Research, 2004, 549:5-27 (Elsevier).
Hsieh, Shu-Chen, et al, “Mouse DDA3 gene is a direct transcriptional target of p53 and -73”,Oncogene, 2002, 21:3050-3057 (Nature).
Liao, Guochun, et al, “In Silico Genetics: Identification of a Functional Element Regulating H2-E{acute over (α)} Gene Expression”,Science, Oct. 22, 2004, 306:690-695.
Lo, Pang-Kuo, et al, “5′-Heterogeneity of mouse Dda3 transcripts is attributed to differential initiation of transcription and alternative splicing”,Arch Biochem and Biophysics, 2004, 425-221-232 (Elsevier).
Lo, Pang-Kuo, et al, “Cloning and characterization of human and mouse DDA3 genes”,Biochemica et Biophysica Acta, 2002, 1579:214-218 (Elsevier).
Puri, Pier Lorenzo, et al, “A mycogenic differentiation checkpoint activated by genotoxic stress”,Nature Genetics, Dec. 2002, 32:585-593.
Van Delft, J.H.M, et al, “Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling”,Carcinogenesis, 2004, 25(7):1265-1276.
Kawai, J., et al, “Functional annotation of a full-length mouse cDNA collection”,Nature, Feb. 2001, 409:685-690 (Macmillan).
“Supplementary Figure 1 Distribution of the length of 21,076 insert DNA's; Supplementary Figure 1B Sequence accuracy”,Nature, 409(6821).
“Supplementary Figure 2 SAP domain containing RIKEN clones”,Nature, 409(6821).
“Supplementary Figure 3A Phylogenetic tree of the known OATPs and new members; Supplementary Figure 3B Alignment of the amino acid sequences of the known OATPs”,Nature, 409(6821).
Afanassiev V et al., “Application of yeast cells transformed with GFP expression constructs containing the RAD54 or RNR2 promoter as a test for the genotoxic potential of chemical substances”,Mutation Research, 2000, 297-308:464.
Ait-Aissa et al., “Induction of the hsp70 gene promoter by various anticancer drugs”, 1999, 651-655:13.
Baumstark-Khan, Christa et al., “Application of the Lux-Fluoro test as bioassay for combined genotoxicity and cytotoxicity measurements by means of recombinantSalmonella typhimuriumTA1535 cells”,Analytica Chimica Acta, 2001, 23-30:437.
Database EMBL, “Mus musculuscDNA clone Image:1746300 5′, mRNA sequence”, 1998, XP02366987, Database accession No. AI037654.
Grover, Judy et al., “Characterization of the human praline/arginine-rich and leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element”,Biochemical Journal, 1998, 77-82:336.
Lo, Pang-Kuo, et al,“Identification of a novel mouse p53 target gene DDA3”,Oncogene, 1998, 7765-7774:18.
Sohn, Taylor A. et al., “High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter”,Carcinogenesis(Oxford), 2002, 949-957:23.
Bains, W., et al., “Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro”,Mol Cell Biol(1984) vol. 4(8): pp. 1449-1453.
Blau, H.M., et al., “Cytoplasmic Activation of Human Nuclear Genes in Stable Heterocaryons”,Cell(1983) vol. 32: pp. 1171-1180.
DePonti-Zilli, L., et al., “A 40-base-pair sequence in the 3′ end of the β-actin gene regulates β-actin mRNA transcription during myogenesis”,Proc Natl Acad Sci USA(1988) vol. 85: pp. 1389-1393.
McMahon, D.K., et al., “C2C12cells: biophysical, biochemical, and immunocytochemical properties”,Am J Physiol(1994) vol. 266:C1795-C1802.
Parmacek, M.S., et al., “The structure and regulation of expression of the murine fast skeletal troponin C gene”,J Biol Chem(1990) vol. 265(26):pp. 15970-15976.
Seiler-Tuyns, A., et al., “Expression and regulation of chicken actin genes introduced into mouse myogenic and nonmyogenic cells”,Proc Natl Acad Sci USA(1984) vol. 81:pp. 2980-2984.
Lo, P., et. al., “Identification of a Novel Mouse p53 Target Gene DDA3,”Oncogene, 1999, vol. 18, pp. 7765-7774.
Newton, R.K., et. al., “The Utility of DNA Microarrays for Characterizing Genotoxicity,”Environmental Health Perspectives2004, vol. 112 (4), pp. 420-422.
Song, K.S., et. al., “Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells,”J. Biol. Chem. 1996, vol. 271 (25), pp. 15160-15165.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for determining genotoxicity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for determining genotoxicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for determining genotoxicity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4153953

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.