Methods for producing macromolecule-identifying polymers

Details Methods for producing macromolecule-identifying polymers Methods for producing macromolecule-identifying polymers

2004-03-05

2010-06-22

Pezzuto, Helen L. (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

C526S199000, C526S200000, C526S303100, C526S307700, C526S323100, C526S323200

Reexamination Certificate

active

07741421

ABSTRACT:
The methods for producing macromolecule identifying polymers according to the present invention comprise the steps of polymerizing a starting monomer in an aqueous solution in the presence of a macromolecule, a crosslinking agent, and a radical polymerization initiator to produce a polymer containing the macromolecule in its interior; and removing the macromolecule from the polymer containing the macromolecule to thereby produce the macromolecule identifying polymer having a molecular imprint of the macromolecule. In this method, the crosslinker has a solubility in water at 25° C. of 100% by mass or higher.

REFERENCES:
patent: 6749811 (2004-06-01), Murray
patent: 2001-55399 (2001-02-01), None
patent: 2003-284947 (2003-10-01), None
patent: 2004-115748 (2004-04-01), None
patent: WO 01/61354 (2001-08-01), None
Byrne et al. Polym. Adv. Technol., 13, 798-816 (2002).
Byrne et al. Mat. Res. Soc. Symp. Proc., 724, N9.3.1-N9.3.7 (2002).
Andersson et al., “Mimics of the binding sites of opioid receptors obtained by molecular imprinting of enkephalin and morphine,”Proc. Natl. Acad. Sci. USA, 92:4788-4792 (May 1995).
Ansell et al., “Towards artificial antibodies prepared by molecular imprinting,”Clinical Chemistry, 42(9):1506-1512 (1996).
Asanuma et al., “Molecular imprinting of cyclodextrin in water for the recognition of nanometer-scaled guests,”Analytica Chimica Acta, 435(1):25-33 (May 2001).
Bossi et al., “Surface-Grafted Molecularly Imprinted Polymers for Protein Recognition,”Analytical Chemistry, 73(21):5281-5286 (Nov. 2001).
Burrow and Minoura, “Molecular Imprinting: Synthesis of Polymer Particles with Antibody-like Binding Characteristics for Glucose Oxidase,”Biochemical and Biophysical Research Communications, 227(2):419-422 (1996).
Hart and Shea, “Synthetic Peptide Receptors: Molecularly Imprinted Polymers for the Recognition of Peptides Using Peptide-Metal Interactions,”J. Am. Chem. Soc., 123(9):2072-2073 (2001).
Hirayama et al., “Synthesis of Polymer-Coated Silica Particles with Specific Recognition Sites for Glucose Oxidase by the Molecular Imprinting Technique,”Chemistry Letters, 27(8):731-732 (1998).
Hjertén et al., “Gels Mimicking Antibodies in Their Selective Recognition of Proteins,”Chromatographia, 44(5/6):227-234 (Mar. 1997).
International Search Report from International Application No. PCT/JP2004/002852.
Kempe et al., “An Approach Towards Surface Imprinting Using the Enzyme Ribonuclease A,”Journal of Molecular Recognition, 8:35-39 (1995).
Piletsky et al., “The rational use of hydrophobic effect-based recognition in molecularly imprinted polymers,”Journal of Molecular Recognition, 11:94-97 (1998).
Rachkov et al., “Molecularly imprinted polymers prepared in aqueous solution selective for [Sar1,Ala8]angiotensin II,”Analytica Chimica Acta, 504:191-197 (Feb. 2004).
Venton and Gudipati, “Influence of protein on polysiloxane polymer formation: evidence for induction of complementary protein-polymer interactions,”Biochimica et Biophysica Acta, 1250:126-136 (1995).
Vlatakis et al., “Drug assay using antibody mimics made by molecular imprinting,”Nature, 361:645-647 (Feb. 1993).
Wulff, “Molecular Imprinting in Cross-Linked Materials with the Aid of Molecular Templates—A Way towards Artificial Antibodies,”Angew. Chem. Int. Ed. Engl., 34:1812-1832 (1995).

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