Fermentation with cyclic pulse-pause feeding

Details Fermentation with cyclic pulse-pause feeding Fermentation with cyclic pulse-pause feeding

2002-06-04

2010-12-21

Ford, Allison M (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

C435S071200, C435S071300, C435S171000, C435S170000

Reexamination Certificate

active

07855059

ABSTRACT:
A process for the production of a valuable compound, comprising the steps of a) fermentation of a filamentous bacterial or fungal strain (e.g. aStreptomycesstrain or anAspergillusstrain) in a fermentation medium wherein a carbohydrate during fermentation is added in a cyclic pulse dosing/pause way, wherein the pulse dosing time is shorter than the pause time and b) recovery of the valuable compound from the fermentation broth.

REFERENCES:
patent: 4468455 (1984-08-01), Hopkins
patent: 1292962 (1991-12-01), None
patent: WO 01/20016 (2001-03-01), None
Li et al., Biotechnology and Bioengineering, vol. 70, No. 3, p. 300-312, (Nov. 5, 2000).
Abstract No. XP-002181125, 1999: 144152 Caplus.
Abstract No. XP-008009695, 1993.
Abstract No. XP-001030780, Biotechnology Letters, vol. 9, No. 9, pp. 617-620 (1987).
Lin et al., Journal of Biotechnology, vol. 79, pp. 27-37, (2000).

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