Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2008-03-03
2010-06-22
Mondesi, Robert B (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S094400, C435S069700, C435S258100, C530S300000, C514S012200
Reexamination Certificate
active
07740857
ABSTRACT:
The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells byP. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.
REFERENCES:
patent: 6551795 (2003-04-01), Rubenfield et al.
patent: 2003/0059436 (2003-03-01), Chishti et al.
patent: WO 02/076380 (2002-10-01), None
patent: WO 2005/018662 (2005-03-01), None
Yamada Tohru et al.; “Bacterial Redox Protein Azurin, Tumor Suppressor Protein p53; and Regression of Cancer.”; Proceedings of the National Academy of Sciences of the United States of America; vol. 99; No. 22; Oct. 29, 2002; pp. 14098-14103; XP002486971.
Gough Julian et al.; “The Linked Conservation of Structure and Function in a Family of High Diversity; The Monomeric Cupredoxins”; Structure (Cambridge); vol. 12; No. 6, Jun. 2004; pp. 917-925; XP002486972.
Yamada et al., “The Bacterial Redox Protein Azurin Induces Apoptosis in J774 Macrophages through Complex Formation and Stabilization of the Tumor Suppressor Protein p53”, Infection and Immunity, vol. 70 (12), Dec. 2002, pp. 7054-7062.
Navy Environment Health Center; Bureau of Medicine and Surgery. “Navy Medical Dept. Pocket Guide to Malaria Prevention and Control.” Technical Manual NEHC-TM PM 6250.1 (Sep. 2000).
Anonymous: “Plastocyanin precursor” Database EMBL, Online, Nov. 1, 1997, XP002306632 abstract.
Anonymous: “Rusticyanin precursor” Database EMBL, Online, Mar. 1, 1992, XP002306633 abstract.
Anonymous: “Pseudoazurin precursor” Database EMBL, Online, Feb. 1, 1991, XP002306634 abstract.
Fundamental Immunology 242 (William E. Paul, M.D. ed., 3d ed. 1993).
Accession No. P00282, 1988.
Hoitink et al., Gene vol. 90, Issue 1, May 31, 1990, pp. 15-20.
Canters and Gilardi FEBS Letters vol. 325, Issues 1-2, Jun. 28, 1993, pp. 39-40.
Yamada, T., et al., “Internalization of bacterial redox protein azurin in mammalian cells:entry domain and specificity”, Cell Microbiol. Oct. 2005; 7(10): 1418-31.
Yamada, T., et al., “Rusticyanin, a bacterial electron transfer protein, causes G1 arrest in J774 and apoptosis in human cancer cells”, Cell Cycle Sep. 2004;3(9):1182-7.
Yamada, T., et al., “Regulation of mammalian cell growth and death by bacterial redox proteins: relevance to ecology and cancer therapy”, Cell Cycle Jun. 2004;3(6):752-5.
Hiraoka, Y., et al., “Modulation of mammalian cell growth and death by prokaryotic and eukaryotic cytochrome c”, Proc Natl Acad Sci U S A. Apr. 27, 2004;101(17):6427-32.
Yamada, T. et al. “Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin”, Proc Natl Acad Sci U S A. Apr. 6, 2004;101(14):4770-5.
Punj, V., et al., “Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer”, Oncogene Mar. 25, 2004; 23(13):2367-78.
Chakrabarty, AM., “Microorganisms and Cancer: Quest for a Therapy”, J. Bacteriol. 185(9):2683-86 , 2003.
Punj, V., et al., “Bacterial cupredoxin azurin and its interactions with the tumor suppressor protein p53”, Biochem Biophys Res Commun. Dec. 5, 2003;312(1):109-14.
Punj, V., et al., “Energy-generating enzymes of Burkholderia cepacia and their interactions with macrophages”, J Bacteriol. May 2003;185(10):3167-78.
Goto, M., et al., “Induction of apoptosis in macrphages byPseudomonas aeruginosaazurin: tumour-suppressor protein p53 and reactive oxygen species, but not redox activity, as critical elements in cytotoxicity”, Mol Microbiol. Jan. 2003;47(2):549-59.
Yamada, T., et al., “The bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53”, Infect Immun. Dec. 2002;70(12): 7054-62.
Yamada, T., et al., “Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer”, Proc Natl Acad Sci U S A. Oct. 29, 2002;99(22):14098-103. Epub Oct. 22, 2002.
Zaborina, O., et al., P2Z-Independent and P2Z receptor-mediated macrophage killing byPseudomonas aeruginosaisolated from cystic fibrosis patients:, Infect Immun. Oct. 1999;67(10):5231-42.
Zaborina, O., et al., “Secreted products of a nonmucoidPseudomonas aeruginosastrain induce two modes of macrophage killing: external-ATP-dependent, P2Z-receptor-mediated necrosis and ATP-independent, caspase-mediated apoptosis”, Microbiology Oct. 2000;146 (Pt 10):2521-30.
Yang, D., et al., “Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells”, Pharmacological Research 2005 52(5):413-421.
Apiyo, D. and Wittung-Stafshede, P., “Unique complex between bacterial azurin and tumor-suppressor protein p53”, Bioche. Biophys. Res. Comm. 2005 332: 965-968.
Ye, Z., et al. “Selective inducement effect of bacterial redox protein azurin on apoptosis of human osteosarcoma cell line U2OS”, Chinese Journal of Cancer 2005, 24(3): 298-304.
Chakrabarty Ananda
Chaudhari Anita
Das Gupta Tapas
Fialho Arsenio
Hong Chang Soo
Baskar Padma V
Mondesi Robert B
Pelto Don J.
Sheppard Mullin Richter & Hampton LLP
The Board of Trustees of the University of Illinois
LandOfFree
Compositions and methods for treating malaria with... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for treating malaria with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for treating malaria with... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4151064