Diagnosis of preeclampsia

Details Diagnosis of preeclampsia Diagnosis of preeclampsia

2005-12-21

2010-06-01

Cook, Lisa V (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C436S501000, C436S518000, C530S300000, C530S350000

Reexamination Certificate

active

07727733

ABSTRACT:
The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnancy, including hypertensive disorders such as preeclampsia, in the first, second, and/or third trimester of pregnancy. The present invention also provides kits for identifying and screening patients at risk of developing a complication of pregnancy, such as preeclampsia.

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Maynard et al. (The Journal of Clinical Investigation, Mar. 2003, vol. 111, No. 5, pp. 649-658).
RJ Levine “Urinary Placental Growth Factor and Risk of Preeclampsia,” JAMA 293(1):77-85 (2005).
Maynard et al., Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111:649-58.
Buhimschi et al., “Urinary Angiogenic Factors Cluster Hypertensive Disorders and Identify Women with Severe Preeclampsia,”American Journal of Obstetrics&Gynecology191(6):S15.

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