Thrombopoietin proteins with improved properties

Details Thrombopoietin proteins with improved properties Thrombopoietin proteins with improved properties

2004-06-25

2009-06-02

Spector, Lorraine (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S351000, C435S069500, C424S198100, C424S192100

Reexamination Certificate

active

07541439

ABSTRACT:
The invention concerns human thrombopoietin and in particular modified forms of thrombopoietin (TPO) with improved properties. The improved proteins contain amino acid substitutions at specific positions within the TPO molecule. The invention provides modified TPO molecules, preferably fusion proteins comprising immunoglobulin constant regions and modified human TPO, with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

REFERENCES:
patent: 5879673 (1999-03-01), Thomas
patent: 6238890 (2001-05-01), Boime et al.
patent: 7101674 (2006-09-01), Le et al.
patent: 7122634 (2006-10-01), Lollar
patent: 7186804 (2007-03-01), Gillies et al.
Park et al., JBC 173(1):256-61, 1998.

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