Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2005-05-26
2009-06-30
Barnhart, Lora E (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S325000, C435S375000, C424S093100
Reexamination Certificate
active
07553663
ABSTRACT:
The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for the production of target cells and target tissue.
REFERENCES:
patent: 5605835 (1997-02-01), Hu et al.
patent: 5731182 (1998-03-01), Boyce
patent: 6090625 (2000-07-01), Abuljadayel
patent: 6294381 (2001-09-01), Olweus et al.
patent: 7112440 (2006-09-01), Abuljadayel
patent: 7220412 (2007-05-01), Abuljadayel
patent: 2001/0049139 (2001-12-01), Lagasse et al.
patent: 2002/0028510 (2002-03-01), Sanberg et al.
patent: 2003/0166272 (2003-09-01), Abuljadayel
patent: 2004/0136973 (2004-07-01), Huberman et al.
patent: WO 98/53048 (1998-11-01), None
patent: WO00/70022 (2000-11-01), None
patent: WO 02/14469 (2002-02-01), None
patent: 2004/043990 (2004-05-01), None
Liu S et al. 1998. Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia. Infection and Immunity 66: 5089-5098.
Bick RL. “Thrombotic and hemorrhagic problems during cardiovascular bypass surgery and cardiovascular procedures.” in Bick, RL, Disorders of Thrombosis and Hemostasis, 3rd ed. (Philadelphia PA USA, Lippincott Williams & Wilkins, 2002), p. 184. RC647 .C55 B583.
Definition of “hepatocyte,” accessed online at http://www.nlm.nih.gov/medlineplus/mplusdictionary.html on Aug. 14, 2008. 1 page.
Hengstler JG et al. 2005. Generation of human hepatocytes by stem cell technology: definition of the hepatocyte. Expert Opin Drug Metab Toxicol 1: 61-74.
Hutchinson JA et al. 2007. Could treatment with neohepatocytes benefit patients with decompensated chronic liver disease? Am J Hematol 82: 947-948.
Lucas et al., “Self-Renewal, Maturation, and Differentiation of the Rat Myelomonocytic Hematopoietic Stem Cell,”The FASEB Journal, 13:263-272 (Feb. 1999), U.S. Appl. No. 10/401,026.
Weissman, “Stem Cells: Units of Development, Units of Regeneration, and Units in Evolution,”Cell, 100:157-168 (Jan. 2000), U.S. Appl. No. 10/401,026.
Weissman, “Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities,”Science, 287:1442-1446 (Feb. 2000), U.S. Appl. No. 10/401,026.
Donovan et al., “The End of the Beginning for Pluripotent Stem Cells,”Nature, 414:92-97 (Nov. 2001), U.S. Appl. No. 10/401,026.
International Search Report from International Application No. PCT/EP03/02121 (WO 03/083091 A1), issued Jun. 18, 2003, U.S. Appl. No. 10/401,026.
International Search Report from International Application No. PCT/EP03/03279 (WO 03/083092 A1), issued Aug. 25, 2003, U.S. Appl. No. 10/401,026.
Barcia et al., “Triglyceride-Rich Lipoproteins as Agents of Innate Immunity”,Clinical Infectious Diseases, 41:5498-5503 (2005).
CD14, Taxonomic Key Program (TKP) at the College of Veterinary Medicine, Washington State University, available online at http://www.vetmed.wsu.edu/tkp/report.aspx?ID=19 (Dec. 2003) 3 pages.
Coyne et al., “Alterations in membrane-associated expression and the simultaneous liberation of soluble CD14 fragment in adherent macrophages mediated by a leukocyte carboxyl/aspartate protease”,Journal of Endotoxin Research, 8(4):273-283 (2002) (abstract only).
Goyert, “Protein Reviews on the Web: CD14”, available online at http://www.sciencegateway.org/resources/prow/guide/2131935697—g.htm (Oct. 1999).
Haziot et al., “The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage”,Journal of Immunology, 141(2):547-552(1988) (abstract only).
Hozumi et al., “Increment of Plasma Soluble CD14 Level in Carrageenan-Primed Endotoxin Shock Model Mice”,Biol. Pharm. Bull., 29(5):1015-1021 (2006).
Kishiwada et al., “Mechanism of Lipopolysaccharide-Induced Decrease of Plasma Protein S: Its Expression in Hepatocytes and Sinusoidal Endothelial Cells is Mediated by NFKB Activation”,Journal of Thrombosis and Haemostasis, 5(1): P0133 (2007) (abstract only).
Li et al., “Lipopolysaccharide induced synthesis of CD14 proteins and its gene expression in hepatocytes during endotoxemia”,World J Gastroenterol, 8(1):124-127 (2002).
U.S. Appl. No. 09/568,254, filed May 2000, Abuljadayel.
Liu et al., “Characterization of rat CD14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytes”,Gene, 250(1-2):137-147 (2000) (abstract only).
Meuleman et al., “Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection”,Clinica Chimica Acta, 366(1-2):156-162 (2006).
Ruhnke et al., “Differentiation of In Vitro-Modified Human Peripheral Blood Monocytes Into Hepatocyte-like and Pancreatic Islet-like Cells”,Gastroenterology, 128:1774-1786 (2005).
Su et al., “CD14 expression and production by human hepatocytes”,Journal of Hepatology, 31(3):435-442 (1999).
Sugawara et al., “Heterogeneous Expression and Release of CD14 by Human Gingival Fibroblasts: Characterization and CD14-Mediated Interleukin-8 Secretion in Response to Lipopolysaccharide”,Infection and Immunity, 66(7):3043-3049 (1998).
Uchida et al., “Involvement of CD14 in Lipopolysaccharide-Induced Liver Injury in Mice Pretreated withPropionibacteriumacnes”,Pathobiology, 71:246-252 (2004).
Celestin et al., “IL-3 Induces B7.2 (CD86) Expression and Costimulatory Activity in Human Eosinophils”,The J Immun, 167:6097-6104 (2001).
Huang et al., “Correlation Between IL-3 Receptor Expression and Growth Potential of Human CD34+Hematopoietic Cells from Different Tissues”,Stem Cells17:265-272 (1999).
Imamura et al., “Induction of MHC class II antigen expression on murine microglia by interleukin-3”,J Neuroimmunol55:119-125 (1994).
Rappold et al., “Functional and Phenotypic Characterization of Cord Blood and Bone Marrow Subsets Expressing FLT3 (CD135) Receptor Tyrosine Kinase”,Blood90(1):111-125 (1997).
Fändrich Fred
Kremer Bernd Karl Friedrich
Ruhnke Maren née Schulze
Arnold & Porter LLP
Barnhart Lora E
Blasticon Biotechnologische Forschung GmbH
LandOfFree
Dedifferentiated, programmable stem cells of monocytic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dedifferentiated, programmable stem cells of monocytic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dedifferentiated, programmable stem cells of monocytic... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4148061