Peptides as solubilizing excipients for transforming growth...

Details Peptides as solubilizing excipients for transforming growth... Peptides as solubilizing excipients for transforming growth...

2007-06-04

2009-12-29

Romeo, David S (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S013800, C514S014800, C514S016700, C530S326000, C530S327000, C530S329000, C530S330000, C530S350000

Reexamination Certificate

active

07638495

ABSTRACT:
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.

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