Process for producing pyrazolecarboxamide derivative

Details Process for producing pyrazolecarboxamide derivative Process for producing pyrazolecarboxamide derivative

1995-10-25

1996-09-17

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544140, 546211, 5483641, C07D23120, C07D23122

Patent

active

055569870

ABSTRACT:
A process for producing a pyrazolecarboxamide derivative represented by formula (C) which comprises reacting a pyrazolecarboxylic ester compound represented by formula (A) with an amine compound represented by formula (B) in the presence of a Lewis acid: ##STR1## wherein R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group; R.sup.2 represents a substituted or unsubstituted alkyl group; and R.sup.3 and R.sup.4 each represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, provided that R.sup.3 and R.sup.4 may be bonded to each other to form a ring.

REFERENCES:
patent: 4348528 (1982-09-01), Breda et al.
patent: 4833246 (1989-05-01), Adachi et al.
R. D. Gless, Jr., Lewis Acid Mediated Aminolysis of Esters: Conversion Of Methyl (S)-(-)-2-Chloropropionate To (S)-(+)-N,N-Diethyl-2-Chloropropionamide, 1986, Synthetic Communications, 16(6), pp. 633-638.
J. I. Levin et al., An Alternative Procedure For the Aluminum-Mediated Conversion Of Esters To Amides, Synthetic Communications, 12(13), pp. 989-993.
F. Porta et al., Reactions Of Esters With Amines Catalysed By Metal Centres, 1988, Gazzetta Chimica Italiana, 118, pp. 475-477.

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