Diazabicyclic aryl derivatives as cholinergy ligands

Details Diazabicyclic aryl derivatives as cholinergy ligands Diazabicyclic aryl derivatives as cholinergy ligands

2005-11-29

2009-11-03

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S336000, C549S505000

Reexamination Certificate

active

07612074

ABSTRACT:
This invention relates to novel diazabicyclic aryl compounds of the formulawherein: R′ represents hydrogen or alkyl; A represents an aromatic monocyclic or bicyclic carbocyclic or heterocyclic; and is hydrogen or a subsituent as defined in the specification. The compounds are cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. The compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

REFERENCES:
patent: 3293251 (1966-12-01), Cignarella et al.
patent: 3328396 (1967-06-01), Kirchner
patent: 2003/0225268 (2003-12-01), Bunnelle et al.
patent: 2005/0250808 (2005-11-01), Xie et al.
patent: 618 813 (1962-10-01), None
patent: 633 541 (1963-10-01), None
patent: WO 95/23152 (1995-08-01), None
patent: WO-2004/016616 (2004-02-01), None
patent: WO-2004/043960 (2004-05-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, p. 205.
Dörwald, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2005, Preface.
Cignarella, et al. J. Med. Chem., 6, 1, 1963, pp. 29-36.
Patani, et al. Chem. Rev., 96, 1996, pp. 3147-3176.
Villa et al., European Journal of Medicinal Chemistry, vol. 36, No. 6, Jun. 2001, pp. 495-506.
Cignarella et al., Farmaco, vol. 53 (10,11), pp. 667-674, 1998.
Fontanella et al., Farmaco, Edizione Scientifica, vol. 30(9), pp. 742-753, (1975).

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