Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1994-10-11
1996-09-17
LeGuyader, John L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530825, 546 88, 435 6, 435 76, 935 76, C07K 1107, C07D47102, C12Q 168
Patent
active
055569498
ABSTRACT:
A class of site-specific DNA cleavage agents comprising a sequence-specific DNA binding protein and a nucleolytic moiety attached thereto at an amino acid that is close to DNA in the specific protein-DNA complex, but that is not close to DNA in the non-specific protein DNA complex. These site-specific DNA cleavage agents cleave DNA at specific DNA recognition sites and have little or no non-specific DNA cleavage activity.
REFERENCES:
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Alber, T. "Mutationed Effects on Protein Stability. " 1989, Ann. Rev. Biochem. 58:765-98.
Sigman, D. S. "Chemical Nucleases. " Biochemistry Nov. 1990 29:9097-105.
Sigman, D. S. and Chen, C. B. "Chemical Nucleases . . . " 1990, Ann. Rev. Biochem. 59:207-36.
Ebright et al., Proc. Natl. Acad. Sci., USA, vol. 87, Apr. 1990, pp. 2882-2886.
Chen et al., Science, vol. 237, Sep. 1987, pp. 1197-1201.
Moser et al., Science, vol. 238, Oct. 30, 1987, pp. 645-650.
Francois et al., Proc. Natl. Acad. Sci. USA, vol. 86, Dec. 1989, pp. 9702-9706.
Ebright Richard H.
Ebright Y. W.
Pendergrast P. Shannon
Larson Thomas G.
LeGuyader John L.
Rutgers University
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