Tumor activated prodrugs

Details Tumor activated prodrugs Tumor activated prodrugs

2006-01-06

2009-12-22

Tsang, Cecilia (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S009100, C530S329000

Reexamination Certificate

active

07635682

ABSTRACT:
The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences: Ser-Ser-Lys-Tyr-Gln (SEQ ID NO:1);Gly-Lys-Ser-Gln-Tyr-Gln (SEQ ID NO:2); and Gly-Ser-Ala-Lys-Tyr-Gln (SEQ ID NO:3) wherein the peptide is linked to the therapeutically active drug to inhibit the therapeutic activity of the drug, and wherein the therapeutically active drug is cleaved from the peptide upon proteolysis by an enzyme having a proteolytic activity of prostate specific antigen (PSA). The invention further provides methods of making and using the claimed compositions.

REFERENCES:
patent: WO 98/52966 (1998-05-01), None
Pinto, The Prostate Journal, 1999, vol. 1, pp. 15-26.

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