Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-05-25
2009-02-24
Shibuya, Mark L. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007910, C435S007920, C436S514000, C436S518000
Reexamination Certificate
active
07494780
ABSTRACT:
The present invention relates to the discovery that an epididymis-specific defensin, EP2D, plays an important role in regulating sperm motility and therefore male fertility. Provided are methods for evaluating male fertility based on the level of EP2D bound to sperm, kits for evaluating male fertility, and methods for enhancing or suppressing fertility in a male by regulating the level of EP2D and the binding between sperm and EP2D.
REFERENCES:
Score Sequence Search Results- 2 pages (See No. 35 rat Bin 1b compared to SEQ ID No. 1 EP2D).
Com, Emmanuelle et al.; “Expression of Antimicrobial Defensins in the Male Reproductive Tract of Rats, Mice, and Humans”; 2003,Biology of Reproduction, vol. 68, pp. 95-104.
Coronel, Carlos E. et al.; “Purification, Structure, and Characterization of Caltrin Proteins from Seminal Vesicle of the Rat and Mouse”; 1992,The Journal of Biological Chemistry, vol. 267, No. 29, pp. 20909-20915.
Dacheux, Jean-Louis et al.; “Contribution of Epididymal Secretory Proteins for Spermatozoa Maturation”; 2003,Microscopy Research and Technique, vol. 61, pp. 7-17.
Fouchecourt, Sophie et al.; “Stallion Epididymal Fluid Proteome: Qualitative and Quantitative Characterization; Secretion and Dynamic Changes of Major Proteins”; 2000,Biology of Reproduction, vol. 62, pp. 1790-1803.
Frolich, Otto et al.; “Organization of the Human Gene Encoding the Epididymis-Specific EP2 Protein Variants and its Relationship to Defensin Genes”; 2001,Biology of Reproduction, vol. 64, pp. 1072-1079.
Henning, Hans von Horsten et al.; “Novel Antimicrobial Peptide of Human Epididymal Duct Origin”; 2002,Biology of Reproduction, vol. 67, pp. 804-813.
Li, Peng et al.; “An Antimicrobial Peptide Gene Found in the Male Reproductive System of Rats”; 2001, Science, vol. 291, pp. 1783-1785.
Yamaguchi, Yasuhiro et al.; “Identification of Multiple Novel Epididymis-Specific β-Defensin Isoforms in Humans and Mice”; 2002,The Journal of Immunology, pp. 2516-2523.
Zasloff, Michael; “Antimicrobial peptides of multicellular organisms”; 2002,Nature, vol. 415, pp. 389-395.
Zhang, Linqi et al.; “Contribution of Human α-Defensin 1, 2, and 3 to the Anti-HIV-1 Activity of CD8 Antiviral Factor”; 2002,Science, vol. 298, pp. 995-1000.
Zhou, Chen Xi et al.; “An epididymis-specific β-defensin is important for the initiation of sperm maturation”; 2004,Nature Cell Biology, vol. 6, No. 5, pp. 458-464.
Chan Hsiao Chang
Chung Yiu Wa
Ng Chuen Pei
Zhou Chenxi
Cheu Changhwa J
Shibuya Mark L.
The Chinese University of Hong Kong
Townsend and Townsend / and Crew LLP
LandOfFree
Epididymis-specific defensin for evaluating and regulating... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Epididymis-specific defensin for evaluating and regulating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epididymis-specific defensin for evaluating and regulating... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4138223