Inhibitors of ion channels

Details Inhibitors of ion channels Inhibitors of ion channels

2006-08-11

2009-11-10

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S274000, C514S365000, C548S197000, C548S205000, C544S310000

Reexamination Certificate

active

07615569

ABSTRACT:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

REFERENCES:
patent: 6262078 (2001-07-01), Loughhead et al.
Priest et al. PNAS 2007, 104(20), 8205-8206.
Chaplan, S.R., et al., “Quantitative Assessment of Tactile Allodynia in the Rat Paw,”J. Neurosci. Methods, 53:55-63 (1994).
Devor, et al.,“Na30Channel Immunolocalization in Peripheral Mammalian Axons and Changes Following Nerve Injury and Neuroma Formation,”J. Neurosci., 13(5):1976-1992 (May 1993).
Kim, et al., “An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat,”Pain, 50:355-363 (1992).
Legroux-Crespel, E., et al., “Traitement de L'érythermalgie Familiale Par L'association Liodocaïne- Mexilétine,”Ann. Dermatol. Venereal, 130:429-33 (2003).
Srivatsa, U. et al., “Mechanisms of Antiarrhythmic Drug Actions and Their Clinical Relevance for Controlling Disorders of Cardiac Rhythm,”Curr. Cardiol. Rep., 4(5):401-410 (Sep. 4, 2002).
Toledo-Aral, et al., “Identification of PN1, a Predominant Voltage-Dependent Sodium Channel Expressed Principally in Peripheral Neurons,”Proc. Natl. Acad. Sci. USA, 94:1527-1532 (Feb. 1997).
Wood, J., et al., “Voltage-Gated Sodium Channels and Pain Pathways,”J. Neurobiol., 61(1):55-71 (Oct. 2004).

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