Benzoyl-tetrahydropiperidine derivatives

Details Benzoyl-tetrahydropiperidine derivatives Benzoyl-tetrahydropiperidine derivatives

2005-12-13

2009-02-03

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S354000, C544S124000, C546S314000

Reexamination Certificate

active

07485637

ABSTRACT:
The present invention relates to compounds of formula Iwherein R1, R2, and Ar; are as defined in the specification. The invention also provides pharmaceutically acceptable acid addition salts thereof and methods for the treatment of neurological and neuropsychiatric disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.

REFERENCES:
patent: 3933802 (1976-01-01), Ferrini et al.
patent: 4122083 (1978-10-01), Sundeen et al.
patent: 4244871 (1981-01-01), Kosary et al.
patent: 7034047 (2006-04-01), Tobe et al.
patent: 7067501 (2006-06-01), Smith et al.
patent: 7427612 (2008-09-01), Alberati-Giani et al.
patent: 7429585 (2008-09-01), Jolidon et al.
patent: 2004/0167166 (2004-08-01), Alberati-Giani et al.
patent: 2005/0059668 (2005-03-01), Alberati-Giani et al.
patent: 2005/0070539 (2005-03-01), Alberati-Giani et al.
patent: 2005/0209241 (2005-09-01), Jolidon et al.
patent: 2533605 (1977-02-01), None
patent: 0 171 636 (1985-02-01), None
patent: 0 624 584 (1994-11-01), None
patent: 0 82 098 (1998-02-01), None
patent: WO 99/44596 (1999-09-01), None
patent: WO 99/45011 (1999-09-01), None
patent: WO 02/22612 (2002-03-01), None
patent: WO 02/074774 (2002-09-01), None
patent: WO 03/004480 (2003-01-01), None
patent: WO 03/035602 (2003-05-01), None
patent: WO 2004/037800 (2004-05-01), None
patent: WO2007/060408 (2007-05-01), None
Lewis D.A. & Lieberman J.A., Neuron. vol. 28, pp. 325-334 (2000).
Vandenberg R. J. & Aubrey K. R., Exp. Opin. Ther. Targets vol. 5(4) pp. 507-518 (2001).
Nakazato A. & Okuyama S., Exp. Opin. Ther. Patents vol. 10(1) pp. 75-98 (2000).
Sharma T., Br. J. Psychiatry, vol. 174 (Suppl. 38) pp. 44-51 (1999).
Javitt D. C. et al., Biol. Psychiatry, vol. 45 pp. 668-679 (1999).
Mohn A. R., Cell vol. 98 pp. 427-436 (1999).
Bliss, T. V. & Collingridge G. L., Nature, vol. 361 pp. 31-39 (1993).
Tang J. P. et al., Nature, vol. 401, pp. 63-69 (1999).
Gainetdinov R. R. et al., Trends in Pharm. Sci. vol. 23(8) pp. 367-373 (2002).
Lopez-Corcuera B, et al., Mol. Mem. Biol. vol. 18 pp. 13-20 (2001).
Bergeron R. et al., Proc. Natl. Acad. Sci. USA vol. 95, pp. 15730-15734 (1998).
Chen et al., J. Neurophysiol. vol. 89(2) pp. 691-703 (2003).
Armer R. E. & Miller D. J., Exp. Opin. Ther. Patents vol. 11(4) pp. 563-572 (2001).
Pralong E. et al., Prog. in Neurobiol. vol. 67, pp. 173-202 (2002).
Carlsson M. L., Neural Trans. vol. 105, pp. 525-535 (1998).
Kwong et al., Org. Lett. 4, pp. 581-584 (2002).
Kuwano et al., JOC 67, pp. 6479-6486 (2002).
Chem. Abstract XP-002299148.
Caulfield W. L. et al., Journal of Med. Chem. vol. 44(17) pp. 2679-2682 (2001).
Chem. Abstract XP-002299149.
Chemical Abstracts Service, 23. Apr. 2003, XP002308402, Database accession No. 2003: 2142911 Chemcats & Catalog: AsInExExpress Gold.
Chemical Abstracts Service, 6. Jun. 2003, XP002308481 & Database Chemcats.
Chemical Abstracts Service, 1. Jan. 2004, XP002308405, Database accession No. 2003:2872406 Chemcats & Catalog: Ambinter Stock Screening Collection.
Chemical Abstracts Service, 1. Jan. 2004, XP002308403, Database accession No. 2004:591813 & Catalog: Ambinter Stock Screening Collection.
Chemical Abstracts Service, 1. Jan. 2004, XP002308404, Database accession No. 2004:660630 & Catalog: Ambinter Screening Library.
Chemical Abstracts Service, XP002308978.
Chemical Abstracts Service, XP002308979; Chemcats No. 2003:1026314.
Chemical Abstracts Service, XP002308980; Chemcats No. 2001;2814605.
Chemical Abstracts Service, XP002308981; Chemcats No. 2002:2063001.
Chemical Abstracts Service, XP002308983; Chemcats No. 2003:1026533.
Chemical Abstracts Service, XP002308984; Chemcats No. 2002:2288893.
Chemical Abstracts Service, XP002308985; Chemcats No. 2003:709504.
Chemical Abstracts Service, XP002308986; Chemcats No. 2003:709503.
Chemical Abstracts Service, XP002308987; Chemcats No. 2003:709505.
Chemical Abstracts Service, XP002308988; Chemcats No. 2004:1498769.
Chemical Abstracts Service, XP002308989; Chemcats No. 2002:2386068.
Chemical Abstracts Service, XP002308990; Chemcats No. 2002:2894607.
Chemical Abstracts Service, XP002308991; Chemcats No. 2003:3342164.
Chemical Abstracts Service, XP002308992; Chemcats No. 2003:3345505.
Chemical Abstracts Service, XP002308993; Chemcats No. 2003:3346187.
Chemical Abstracts Service, XP002309007; Chemcats No. 2004:660630.
Abstract corresponding to Document B5-WO 03/035602.
Cabiddu et al., Journal of Organometallic Chemistry, 1991, 419(1-2) 1-8.
Collins, et al., J. Med. Chem. 1998, 41, p. 5037-5054.
Abstract corresponding to Document B10-DE2533605.

Affiliated with

Also associated with

Rating

Benzoyl-tetrahydropiperidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzoyl-tetrahydropiperidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzoyl-tetrahydropiperidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4136914