Method for stimulating the immune, inflammatory or...

Details Method for stimulating the immune, inflammatory or... Method for stimulating the immune, inflammatory or...

2005-03-15

2009-08-04

Lewis, Patrick T (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S043000, C514S048000

Reexamination Certificate

active

07569555

ABSTRACT:
Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune response to a vaccine by serving as an adjuvant. Cyclic di-GMP, or a cyclic dinucleotide analogue thereof, also has neuroprotective properties for use as a neuroprotective agent to inhibit, treat, or ameliorate the effects of injuries, diseases, disorders or conditions that result in neurodegeneration.

REFERENCES:
patent: 2005030182 (2005-04-01), None
Kawai et al. Nucleic Acids Research Supplement No. 3 (2003), pp. 103-104.
Steinberger et al. FEBS Letters, vol. 444, No. 1, pp. 125-129, 1999.
Mayer et al. PNAS USA, vol. 88, pp. 5472-5476, 1991.
Tischler et al., Cyclic diguanylate (c-di-GMP) regulates Vibrio cholerae biofilm formation, Molecular Microbiology, 53 (3)857-869 (2004).

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