Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-12-22
1996-09-17
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 711, 4352401, 4352523, 4353201, 536 231, 536 235, 536 243, 536 2431, 935 11, 935 22, 935 66, 935 72, C12N 1512, C07K 1452
Patent
active
055567673
ABSTRACT:
There is disclosed a human macrophage inflammatory protein-1 .gamma. (MIP-1 .gamma.) polypeptide and DNA(RNA) encoding such polypeptide. There is also provided a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of various associated diseases.
REFERENCES:
Clements, J. M. et al., Biological and Structural Properties of MIP-1 Alpha Expressed in Yeast, CytoKine, 4:76-82 (1992).
Graham, G. J. and Pragnell, I. B., SCI/MIP-1 Alpha: a Patent Stem Cell Inhibitor with Potential Roles in Development, Dev. Biol., 151:377-81 (1992).
Lukacs,. N. W., et al., The Role of MIP-1 Alpha in Schistosoma egg-induced granulomatous inflammation, J. Exp. Med., 177:1551-9 (1993).
Wolpe, S. D., and Cerami, A., MIPs 1 and 2: Members of a Novel Superfamily of Cytokins, FASEB J., 3:2565-73 (1989).
Adams Mark D.
Li Haodong
Rosen Craig A.
Ruben Steven
Ferraro Gregory D.
Human Genome Sciences Inc.
Mertz Prema
Olstein Elliot M.
Walsh Stephen G.
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