Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2004-04-15
2009-06-16
Campell, Bruce (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S009200, C424S159100
Reexamination Certificate
active
07547442
ABSTRACT:
The invention relates to the process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from said process. The process offers the possibility to modify the NDV genome by means of genetic modification and allows the introduction of mutations, deletions and/or insertions. The process can be used to modify the virulence of NDV, thereby generating new attenuated live vaccines with enhanced properties. The process can be used to modify the antigenic make-up of NDV, thus allowing the generation of live NDV marker vaccines which can be serologically distinguished from NDV field strains.
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de Leeuw Olav Sven
Gielkens Arnoud Leonard Josef
Koch Guus
Peeters Bernardus Petrus Hubertus
Campell Bruce
Hurt Sharon
ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V.
TraskBritt
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