Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1994-03-15
1996-09-17
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
514863, A61K 740, A61K 742
Patent
active
055566120
ABSTRACT:
Method for treating a proliferative skin disorder, such as psoriasis, in a human patient having affected and non-affected areas of skin. The method comprises the steps of: (1) topically applying a sunscreen providing photo-protection to the affected and non-affected areas of skin; (2) waiting for a time period sufficient for the skin of the affected areas to be substantially sloughed off; and, (3) exposing the affected and non-affected areas of skin of the patient to a selected level of optical radiation. The level of radiation is chosen to be sufficient to treat the affected areas of skin and insufficient to cause significant damage to the non-affected areas of skin. The method enhances effectiveness and safety of treatment by providing preferential photo-protection to the non-affected skin areas, and may be used for phototherapy, photochemotherapy, or photodynamic therapy.
REFERENCES:
patent: 2949403 (1960-08-01), Andreadis et al.
patent: 4325965 (1982-04-01), Chiba
patent: 4454159 (1984-06-01), Musher
patent: 4651739 (1987-03-01), Oseroff et al.
patent: 4981681 (1991-01-01), Tosti
patent: 5112613 (1992-05-01), Honda et al.
patent: 5122536 (1992-06-01), Perricone
patent: 5126135 (1992-06-01), Yamada et al.
Fowlks, The Journal of Investigative Dermatology, 1959, vol. 32, "The Chemistry of Psoralens" pp. 249-254.
Pathak et al, The Jounal of Investigative Dermatology, 1959, vol. 32, pp. 255-262.
Follett et al., "Protection of Photosensitized Rats against Long Ultraviolet Radiation by Topical Application of Compounds with Structures Similar . . . Dihydroxyacetone" Dermatologica, 175:58-63 (1987).
Levy et al., "Dihydroxyacetone-containing sunless or self-tanning lotions" J. Amer. Acad. of Dermatology, 27:989-993 (1992).
Lui et al., "Photodynamic Therapy in Dermatology" Arch. Dermatol., 128:1631-1636 (1992).
Maibach et al., "Dihydroxyacetone: A Suntan-Simulating Agent" Archives of Dermatology, pp. 505-507, (1960).
Takahashi et al., "Measurement of turnover time of stratum corneum using dansyl chloride flourescence" J. Soc. Cosmet. Chem., 38:321-331 (1987).
Weinstein et al., "Low Dose Photofrin II Photodynamic Therapy of Psoriasis" Clinical Research, 39:509A (1991).
Weinstein et al., "Cell Kinetic Basis for Pathophysiology of Psoriasis" J. Investigative Dermatology, 55:579-583, (1985).
Kawada, A. et al., Acta Derm. Venereol., vol. 69, pp. 335-337 (1989).
Van Praag, M. C. G. et al., J. Invest. Derm., vol. 97(4), pp. 629-633 (1991).
Rippke, F. et al., Puva Therapy of Psoriasis, vol. 69(10), pp. 671-676 (1994).
Fitzpatrick et al., "Historical Aspects of Methoxsalen and Other Furocoumarins," J. of Investigative Dermatology, 32:229-231, 1959.
Fowlks et al., "The Mechanism of the Photodynamic Effect," J. of Investigative Dermatology, 32:233-243, 1959.
Stegmaier, "The Use of Methoxsalen in Sun Tanning," J. of Investigative Dermatology 32:345-349, 1959.
PCT International Search Report for PCT/US95/03130 (mailed Jun. 15, 1995).
Anderson R. Rox
Hruza Luciann
Kollias Nikiforos
Dodson Shelley A.
The General Hospital Corporation
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