Multidentate arrays

Details Multidentate arrays Multidentate arrays

2002-10-15

2009-02-10

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

Reexamination Certificate

active

07488575

ABSTRACT:
A method of evaluating for the presence of a target polynucleotide in a sample, using an addressable array of multiple polynucleotide probes linked to a substrate. The sample is exposed to the array and a set of polynucleotide target probes, such that target polynucleotide which may be present will bind to a predetermined feature of the array through multiple target probes of the set by forming at respective target regions on a target molecule, simultaneous hybrids with anti-target regions of the multiple target probes. A binding pattern on the array is observed and the presence of the target polynucleotide evaluated based on the observed binding pattern. Kits using such arrays, and methods for selecting target probes are further provided.

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Gentalen, E. and Chee, M., “A Novel Method for Determining Linkage Between DNA Sequences: Hybridization to Paired Probe Arrays”, Nucleic Acids Research, 1999, vol. 27, No. 6, pp. 1485-1491.

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