Heterarylpiperidine modulators of chemokine receptor activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S207000, C546S208000, C546S209000, C546S210000, C546S211000

Reexamination Certificate

active

07491737

ABSTRACT:
The present invention is directed to compounds of the formula (I): (wherein R1, R2, R3, R4, R5, R6, R10and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

REFERENCES:
patent: 5843966 (1998-12-01), Armou et al.
patent: 6140338 (2000-10-01), Naya et al.
patent: 6248755 (2001-06-01), Chapman et al.
patent: 6498161 (2002-12-01), Caldwell et al.
patent: 6531484 (2003-03-01), Willoughby et al.
patent: 2005/0250814 (2005-11-01), Zhou et al.
patent: 2005/0261325 (2005-11-01), Butora et al.
patent: 2006/0116421 (2006-06-01), Butora et al.
patent: 2006/0173013 (2006-08-01), Zhou et al.
patent: WO 02/13824 (2002-01-01), None
patent: WO/0213824 (2002-02-01), None
patent: WO 2004/110376 (2004-12-01), None
Xia et. al. “Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists” Bioorganic & Medicinal Chemistry Letters 2007; 17, 5964-5968.
Anthony B. Pinkerton “Diaryl substituted pyrazoles as potent CCR2 receptor antagonists” Bioorganic & Medicinal Chemistry Letters 2007, 17, 807-813.
Yang et. al. “Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists” Bioorganic & Medicinal Chemistry Letters 2006, 16, 3735-3739.
Pozharskii et. al. Heterocycles in Life and Society Wiley, 1997, pp. 1-6.

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