Methods for producing target cell reactive lymphocytes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S185100, C530S328000

Reexamination Certificate

active

07598223

ABSTRACT:
Methods and compositions for producing target cell reactive lymphocytes, e.g., cytolytic T-lymphocytes, in a subject are provided. In practicing the subject methods, a lymphocyte population is contacted with an effective amount of a target cell peptide mixture of active and inactive peptides to produce lymphocytes reactive, e.g., cytolytic, for the target cell. Also provided are compositions, kits, and systems for practicing the subject methods. The subject invention finds use in a variety of different applications, including therapeutic applications.

REFERENCES:
Thumann, P., et al. Antigen loading of dendritic cells with whole tumor cell preparations. J. Immunol. Methods. 2003. vol. 277, pp. 1-16.
Mitchell MS., et al. Active specific immunotherapy for melanoma: Phase I trial of allogeneic lysates of a novel adjuvant. Cancer Res. 1988. vol. 48, pp. 5883-5893.
Sosman JA, et al. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Impact of HLA class I antigen expression on outcome. J. Clin. Oncol. 2002. vol. 20, pp. 2067-2075.
Bullock et al., Antigen Density Presented by Dendritic Cells in vivo Differentially Affects the Number and Avidity of Primary, Memory, and Recall CD8+T Cells1, The J. of Immunol., 2003, 170: 1822-1829.
Oh et al., Selective Induction of High Avidity CTL by Altering the Balance of Signals From APC, The J. of Immun., 2003, 170: 2523-2530.
Xu et al., Rapid High Efficiency Sensitization of CD8+T Cells to Tumor Antigens by Dendritic Cells Leads to Enhanced Functional Avidity and Direct Tumor Recognition Through an IL-12-Dependent Mechanism1, The J. of Immun., 2003, 171: 2251-2261.
Marchand et al., Biological and clinical developments in melanoma vaccines, Ashley Publications Ltd., 2001, 1451-2598.
Rammensee et al., Molecular Biology Intelligence Unit-MHC Ligands and Peptide Motifs, Landes Bioscience, 1997, Springer-Verlag, Heidelberg, Germany.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for producing target cell reactive lymphocytes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for producing target cell reactive lymphocytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for producing target cell reactive lymphocytes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4101797

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.