Processes and intermediates for preparing benzyl epoxides

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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C564S342000

Reexamination Certificate

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07638646

ABSTRACT:
Disclosed are intermediates and processes for preparing epoxides of the formula:where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.

REFERENCES:
patent: 5482947 (1996-01-01), Tally et al.
patent: 5508294 (1996-04-01), Vazquez et al.
patent: 5510349 (1996-04-01), Tally et al.
patent: 5760064 (1998-06-01), Vazquez et al.
patent: 5965588 (1999-10-01), Vazquez et al.
patent: 0 382 463 (1990-08-01), None
patent: 0 963 972 (1999-12-01), None
patent: WO 98/33795 (1998-08-01), None
patent: WO 02/02505 (2002-01-01), None
patent: WO 02/02512 (2002-01-01), None
Lankiewicz et al., Bioorganic Chemistry, 1989, 17(3), 275-280, Abstract.
Krause et al., Chirality, 1996, 8(2), 173-188.
West et al., Organic Letters, 1999, 1(11), 1819-1822.
Moriniere et al., Synthetic Communications, 1988, 18(4), 441-444, Abstract.
Barluenga et al., “Highly Diastereoselective Synthesis of Threo or Erythro Aminoalkyl Epoxides from a-Amino Acids”,J. Org. Chem., vol. 60, No. 21, 1995, 6696-6699.
Barluenga et al., “The First Direct Preparation of Chiral Functionalised Ketones and their Synthetic Uses”,J. Chem. Soc., Chem. Commun., 1994, pp. 969-970, ISSN 0022-4936.
Burk et al., “Preparation and Use of C2-Symmetric Bis(phospholanes): Production of a-Amino Acid Derivatives via Highly Enantioselective Hydrogenation Reactions”,J. Am. Chem. Soc., 1993, 115, 10125-10138.
Getman et al., “Discovery of a Novel Class of Potent HIV-1 Protease Inhibitors Containing the (R)-(Hydroxyethyl) urea Isostere”,J. Med. Chem., 1993, 36, 288-291.
Hauptman et al., “Synthesis of Novel (P,S) Ligands Based on Chiral Nonracemic Episulfides. Use in Asymmetric Hydrogenation”,Organometallics, 1999, 18, 2061-2073.
Parkes et al., “Studies toward the Large-Scale Synthesis of the HIV Proteinase Inhibitor Ro 31/8959”,J. Org. Chem., 1994, 59, 3656-3664.
Raddatz et al., “Substrate Analogue Renin Inhibitors Containing Replacements of Histidine in P2 or Isosteres of the Amide Bond between P3 and P2 Sites”,J. of Medical Chemistry, 1991, vol. 34, No. 11.
RajanBabu et al., “Carbohydrate Phosphinites as Practical Ligands in Asymmetric Catalysis: Electronic Effects and Dependence of Backbone Chirality in Rh-Catalyzed Asymmetric Hydrogenations. Synthesis of R- or S-Amino Acids Using Natural Sugars as Ligand Precursors”,J. Org. Chem., 1997, 62, 6012-6028.
Wang et al., “Preparation of a-Chloroketones by the Chloroacetate Claisen Reaction”,Synlett, 2000, No. 6, 902-904, ISSN 0936-5214.

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