Prostaglandin EP 4 antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S183000, C514S913000

Reexamination Certificate

active

07612082

ABSTRACT:
Disclosed herein are methods and compositions related to compound 1 or compound 2or pharmaceutically acceptable salts, or prodrugs thereof, which are antagonists of a prostaglandin EP4receptor, or are prostaglandin EP4antagonists.

REFERENCES:
patent: 4166452 (1979-09-01), Generales, Jr.
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen et al.
patent: 4812448 (1989-03-01), Knepper
patent: 6369089 (2002-04-01), Burk et al.
patent: 6956057 (2005-10-01), Woodward et al.
patent: 2005/0147648 (2005-07-01), Gierhart
patent: 2006/0030606 (2006-02-01), Old et al.
patent: WO00/15608 (2000-03-01), None
patent: WO01/49661 (2001-07-01), None
Suzawa et al., The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resporption: An Analysis Using Specific Agonists for the Respective EPs, 2000, Endocrinology, vol. 141, No. 4, pp. 1554-1559.
Database Chemcats, STN; AN: 2003:2283722; Apr. 25, 2003, XP 002368290.
Database Registry, STN; RN: 468093-79-0; Oct. 31, 2002, XP 002368291.
Database Registry, STN; RN: 468713-77-1; Nov. 1, 2002, XP 002368292.
Database Registry, STN; RN: 339310-56-4; Jun. 4, 2001, XP 002368293.

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