Preparation of tetrakis [3-(3,5-di-tert-butyl-4-hydroxy...

Details Preparation of tetrakis [3-(3,5-di-tert-butyl-4-hydroxy... Preparation of tetrakis [3-(3,5-di-tert-butyl-4-hydroxy...

2004-10-27

2009-10-13

Zucker, Paul A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

Reexamination Certificate

active

07601862

ABSTRACT:
A transesterification process for the preparation of tetrakis [3-(3,5-di-tert-butyl-4-hydroxy phenyl)propionyl oxymethyl] methane by the reaction of methyl-(3,5-di-tert-butyl-4-hydroxy phenyl)propionate ester with pentaerythritol wherein the reaction takes place in the presence of an ester exchange catalyst combination consisting of (a) at least one basic or neutral catalyst and (b) at least one metal compound capable of behaving as a Lewis acid and wherein the reaction is conducted through a first stage in which only basic or neutral catalyst is present in the reaction mixture followed by a second stage which commences with the addition of Lewis acid catalyst to the reaction mixture when the amount of di-substituted intermediate product contained within the reaction mixture is less than 20 area % analyzed by HPLC.The preferred basic catalysts are lithium hydroxide and lithium hydroxide monohydrate.The preferred Lewis acid catalyst is zinc octanoate.

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