Polynucleotides encoding polypeptides that bind to the P185...

Details Polynucleotides encoding polypeptides that bind to the P185... Polynucleotides encoding polypeptides that bind to the P185...

2005-09-12

2009-10-13

Hayes, Robert C (Department: 1649)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07601827

ABSTRACT:
Novel 2 polypeptides with binding affinity for the p185HER2receptor, designated heregulin 2-α and heregulin 2-β, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-α has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-α useful in the production of heregulin 2-α by recombinant means. Further provided an amino acid sequence of heregulin 2-α and heregulin 2-β. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.

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