Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2002-10-03
2009-12-22
Huff, Sheela J (Department: 1643)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023500
Reexamination Certificate
active
07635686
ABSTRACT:
The present invention provides a composition comprising a 5′-OH, 3′-TEG cholesteryl synthetic sequence wherein the sequence is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8. The present invention provides methods of using this composition for induction of response in a cell, including but not limited to inhibition of cellular proliferation, induction of cell cycle arrest, induction of caspase activation, cleavage of poly(ADP-ribose) polymerase, induction of apoptosis or modulation of extracellular matrix-cell interactions, or combinations thereof, in cancer cells or synovial cells, and methods of using this composition for treating disease.
REFERENCES:
patent: 4958013 (1990-09-01), Letsinger
patent: 6881381 (2005-04-01), Asher et al.
patent: 6881831 (2005-04-01), Iyer et al.
patent: 7087586 (2006-08-01), Filion et al.
patent: 2001/0041681 (2001-11-01), Phillips et al.
patent: WO 96/23508 (1996-08-01), None
patent: WO 97/14440 (1997-04-01), None
patent: WO-99/011813 (1999-03-01), None
patent: WO-00/008141 (2000-02-01), None
patent: WO 00/09073 (2000-02-01), None
patent: WO 01/44465 (2001-06-01), None
Bates, P.J., et al. “Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding”,The Journal of Biological Chemistry, vol. 274, No. 37, pp. 26369-26377, Sep. 10, 1999.
Boutorin, A.S., et al. “Synthesis of Alkylating Oligonucleotide Derivatives Containing Cholesterol or Phenazinium Residues at Their 3′-terminus and Their Interaction with DNA Within Mammalian Cells”,FEBS Letters, vol. 254, No. 1,2, pp. 129-132, Aug. 28, 1989.
Corrias, M.V., et al., “Bioavailability of Antisense Oligonucleotides in Neuroblastoma Cells: Comparison of Efficacy Among Different Types of Molecules”,Journal of Neuro-Oncology, vol. 31, pp. 171-180, 1997.
EPA, W.R., et al., “Enhanced Downregulation of the p75 Nerve Growth Factor Receptor by Cholesteryl and Bis-Cholesteryl Antisense Oligonucleotides”,Antisense&Nucleic Acid Drug Development, vol. 8, pp. 489-498, 1998.
Green, S.K., et al., “Adhesion-dependent Multicellular Drug Resistance”,Anti Cancer Drug Design, vol. 14, pp. 153-168, 1999.
Hackett, A.J., et al., “Two Syngeneic Cell Lines from Human Breast Tissue: The Aneuploid Mammary Epithelial (Hs578T) and the Diploid Myoepithelial (Hs578Bst) Cell Lines”,J. Natl. Cancer Inst., vol. 58, No. 6, pp. 1795-1806, Jun. 1977.
Herrera-Gayol, A., et al., “Effects of Hylauronan on the Invasive Properties of Human Breast Cancer Cells in Vitro”,Int. J. Emp. Path., vol. 82, pp. 193-200, 2001.
Koopman, G., et al., “Annexin V for Flow Cytometric Detection of Phosphatidylserine Expression on B Cells Undergoing Apoptosis”,Blood, vol. 84, No. 5, pp. 1415-1420, Sep. 1, 1994.
Krawczyk, C.M., et al., “Protective Specific Immunity Induced by Cyclophosphamide Plus Tumor Necrosis Factor α Combination Treatment of EL4-limphoma-bearing C57BL/6 Mice”,Cancer Immunol Immunother, vol. 40, pp. 347-357, 1995.
Letsinger, R.L., et al., “Cholesteryl-conjugated Oligonucleotides: Synthesis, Properties, and Activity as Inhibitors of Replication of Human Immunodeficiency Virus in Cell Culture”,Proc. Natl. Acad. Sci. USA, vol. 86, pp. 6553-6556, Sep. 1989.
Martin, S.J., et al., “Early Redistribution of Plasma Membrane Phosphatidylserine Is a General Feature of Apoptosis Regardless of the Initiating Stimulus: Inhibition by Overexpression of Bcl-2 and Abl”,J. Exp. Med., vol. 182, pp. 1545-1556, Nov. 1995.
O'Brian, M.A., et al., “Poly (ADP-Ribose) Polymerase Cleavage Monitored In Situ in Apoptotic Cells”,Biotechniques, vol. 30, pp. 886-891, Apr. 2001.
Price, J.E., et al., “Tumorigenicity and Metastasis of Human Breast Carcinoma Cell Lines in Nude Mice”,Cancer Research, vol. 50, pp. 717-721, Feb. 1, 1990.
Peiper, M., et al., “Human Pancreatic Cancer Cells (MPANC-96) Recognized by Autologous Tumor-Infiltrating Lymphocytes After in Vitro as Well as in Vivo Tumor Expansion”,Int. J. Cancer, vol. 71, pp. 993-999, 1997.
Radisky, D., et al., “Tumors are Unique Organs Defined by Abnormal Signaling and Context”,Cancer Biology, vol. 11, pp. 87-95, 2001.
Saxon, M., et al., “Stimulation of Calcium Influx in HL60 Cells by Cholesteryl-Modified Homopolymer Oligodeoxynucleotides”,Antisense Research and Development, vol. 2, pp. 243-250, 1992.
Scaggiante, B., et al., “Human Cancer Cell Lines Growth Inhibition by GTnOligodeoxyribonucleotides Recognizing Single-Stranded DNA-binding Proteins”,Eur. J. Biochem., vol. 252, pp. 201-215, 1998.
Stein, C.A., et al., “Mode of Action of 5′-Linked Cholesteryl Phosphorothioate Oligodeoxynucleotides in Inhibiting Syncytia Formation and Infection by HIV-1 and HIV-2 in Vitro”,Biochemistry, vol. 30., pp. 2439-2444, 1991.
Susin, S.A., et al., “The Central Executioner of Apoptosis: Multiple Connections Between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-Induced Apoptosis”,J. Exp. Med., vol. 186, No. 1, pp. 25-37, Jul. 7, 1997.
Takeo, T., et al., “New Xenografts of Human Megakaryoblastic Cell Line (MEG-01) for Evaluating Anti-Tumor Agents”,Leukemia, vol. 7, No. 8, pp. 1268-1274, Aug. 1993.
Thompson, E.W., et al., “Association of Increased Basement Membrane Invasiveness with Absence of Estrogen Receptor and Expression of Vimentin in Human Breast Cancer Cell Lines”,Journal of Cellular Physiology, vol. 150, pp. 534-544, 1992.
Thornberry, N.A., et al., “A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B”,Journal of Biological Chemistry, vol. 272, No. 29, pp. 17907-17911, Jul. 18, 1997.
Vlassov, V.V., et al., “Transport of Oligonucleotides Across Natural and Model Membranes”,Biochimica et Biophysica Acta, vol. 1197, pp. 95-108, 1994.
Wagner, W.R., “Gene Inhibition Using Antisense Oligodeoxynucleotides”,Nature, vol. 372, pp. 333-335, Nov. 24, 1994.
Weaver, V.M., et al., “Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies”,Journal of Cell Biology, vol. 137, No. 1, pp. 231-245, Apr. 7, 1997.
Wyllie, A.H., et al., “Cell Death: The Significance of Apoptosis”,International Review of Cytology, vol. 68, pp. 251-307, 1980.
Filion Mario C.
Herréra Gayol Andrea C.
Phillips Nigel C.
Bioniche Life Sciences Inc.
Huff Sheela J
Kilpatrick & Stockton LLP
LandOfFree
Therapeutically useful triethyleneglycol cholesteryl... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapeutically useful triethyleneglycol cholesteryl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutically useful triethyleneglycol cholesteryl... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4094506