Apolipoprotein A1 mimetics and uses thereof

Details Apolipoprotein A1 mimetics and uses thereof Apolipoprotein A1 mimetics and uses thereof

2005-07-15

2009-08-04

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S326000

Reexamination Certificate

active

07569546

ABSTRACT:
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also provides pharmaceutical compositions and methods of treatment for elevated levels of plasma cholesterol.

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patent: 2006/0234908 (2006-10-01), Fogelman
Fischer. The Design, Synthesis and Application of Stereochemical and Directional Peptide Isomers: A Critical Review. Current Protein and Peptide Science. 2003, vol. 4, pp. 339-356.
Navab, N. et al., “Oral Administration of an Apo A-I Mimetic Peptide Synthesized From D-Amino Acids Dramatically Reduces Atherosclerosis in Mice Independent of Plasma Cholesterol”,Circuilation, 105(3):290-292 (Jan. 22, 2002).
International Search Report dated May 18, 2006.

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