Use of cytokine receptors as biomarkers and therapeutic...

Details Use of cytokine receptors as biomarkers and therapeutic... Use of cytokine receptors as biomarkers and therapeutic...

2006-08-30

2009-10-06

Nickol, Gary B (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C536S023100, C536S024300, C530S350000

Reexamination Certificate

active

07598057

ABSTRACT:
Nucleic acids encoding erythropoietin receptor isoforms are described, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.

REFERENCES:
Arcasoy et al., Biochem. Biophys. Res. Comm., 2003, vol. 307(4):999-1007.
Amgen, Inc., “Influence of Erythropoietic Stimulating Agents (ESAS) on Tumor Progression and Survival”, 2007 ODAC Meeting Information Package, pp. 127-203.
International Search Report for PCT/US03/27368, Jun. 29, 2007.
Arcasoy M O, et al. Expression of erythropoietin receptor splice variants in human cancer. Biochemical and Biophysical Research Communications. 2003. vol. 307, pp. 999-1007.
Acs G, et al. Erythropoietin and Erythropoietin Receptor Expression in Human Cancer. Cancer Research. May 1, 2001. vol. 61, pp. 3561-3565.
Mittelman M, et al. Analysis of the erythropoietin receptor gene in patients with myeloproliferative and myelodysplastic syndromes. Leukemia Research. 1996. vol. 20, No. 6, pp. 459-466.
Eck S L and Wilson J M. 1996, in: Goodman and Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, McGraw-Hill, New York.
Noguchi et al., Cloning of the Human Erythropoietin Receptor Gene,Blood, vol. 78, No. 10:2548-2558 (1991).
Nakamura et al., A Truncated Erythropoietin Receptor That Fails to Prevent Programmed Cell Death of Erythoid Cells,Science, vol. 257:1138-1141 (Aug. 21, 1992).

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