PRO214 polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S866000

Reexamination Certificate

active

07619062

ABSTRACT:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those peptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

REFERENCES:
patent: 5395760 (1995-03-01), Smith et al.
patent: 5888774 (1999-03-01), Delcuve
patent: 6881823 (2005-04-01), Ruben et al.
patent: 7094567 (2006-08-01), Botstein et al.
patent: 2003/0027998 (2003-02-01), Holtzman et al.
patent: 2003/0059828 (2003-03-01), Ashkenazi et al.
patent: 2003/0130489 (2003-07-01), Ashkenazi et al.
patent: 2005/0170465 (2005-08-01), Ferrara et al.
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, Merz and Le Grand (Eds), Aug. 1994, Springer Verlag, pp. 433 and 492-495.
Brandt et al. Identification and biological characterization of an epidermal growth factor related protein: cripto 1. J Biol Chem. Jun. 24, 1994;269(25):17320 8.
Eib et al. A novel transmembrane protein with epidermal growth factor and follistatin domains expressed in the hypothalamo-hypophysial axis ofXenopus laevis. J Neurochem. Sep. 1996;67(3):1047-55.
Engler et al. Human epidermal growth factor. Distinct roles of tyrosine 37 and arginine 41 in receptor binding as determined by site-directed mutagenesis and nuclear magnetic resonance spectroscopy. FEBS Lett. Oct. 1, 1990;271(1-2):47-50.
Smas et al. Pref 1, a protein containing EGF like repeats, inhibits adipocyte differentiation. Cell. May 21, 1993;73(4):725 34.
Carpenter et al. Epidermal growth factor. J Biol Chem. May 15, 1990;265(14):7709 12.
U.S. Appl. No. 09/312,359.
U.S. Appl. No. 09/251,329.
Iruela-Arispe et al. Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF-beta 1. J Cell Biochem. Aug. 1993;52(4):414-30.
Ashkenazi et al; “Sixty one nuleic acids encoding PRO polypeptides which are useful in the treatment of skin diseases, cancers and neurodegenerative diseases”, GenBank Accession No. P—AAF72391; WO200104311-A1, Feb. 22, 2000; Pub Date: Jan. 18, 2001.
Botstein et al; “New antibody that binds to a PRO polypeptide, useful for diagnosing and treating cancers”, GenBank Accession No. P—AAF60352; WO200105836-A1, Dec. 20, 1999; Pub Date Jan. 25, 2001.
Goddard et al; “New isolated antibodies which bind to specific polypeptides used for diagnosis and treatment of neoplastic cell growth and proliferation”; GenBank Accession No. P—AAA30032; WO200015666-A2, Sep. 8, 1999; Pub Date: Mar. 23, 2000.
Ashkenazi et al; “Nucleic acids encoding PRO polypeptides useful for preventing, diagnosing and treating diagnosing a cardiovascular, endothelial or angiogenic disorders in mammals”, GenBank Accession No. P—AAA77541; WO200032221-A2, Nov. 30, 1999; Pub Date Jun. 8, 2000.
Botstein et al; “Antibodies against specific proteins overexpressed in tumours”, GenBank Accession No. P—AAX28431; WO9914327-A2, Sep. 10, 1998; Pub Date Mar. 25, 1999.
Chen, et al; “New isolated human genes and polypeptides used in, e.g. treatment of gastrointestinal ulceration”, GenBank Accession No. P—AAX52233; WO9914328-A2, Sep. 16, 1998; Pub Date Mar. 25, 1999.
Botstein et al; “Polypeptidic ccompositions and methods for the treatment of tumors”, GenBank Accession No. AX076899; WO 0105836-A 11, Jan. 25, 2001.
Pan, Y and Leiby, K.R.; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAC84379; WO200069885-A2, GenBank Accession No. May 15, 2000; Pub Date: Nov. 23, 2000.
Bandman et al; “Isolated polynucleotide encoding extracellular matrix or adhesion-associated protein (EXMAD) useful for diagnosing, treating, or preventing disorders associated with expression of EXMAD such as proliferative, immune and genetic disorders”, GenBank Accession No. P—AAC66895; WO200068380-A2, May 10, 2000; Pub Date: Nov. 16, 2000.
Pan, Y and Leiby, K.R.; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, GenBank Accession No. P—AAC84403; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Pan, Y and Leiby, K.R.; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, GenBank Accession No. P—AAC84401; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Bandman et al; “Extracellular matrix and adhesion-associated proteins”, GenBank Accession No. AX047345; WO 0068380-A 31, Nov. 16, 2000.
Rupp et al; “Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins”, GenBank Accession No. NM—015513; Gene 293 (1-2), 47-57 (2002).
Wiemann et al; “Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”, GenBank Accession No. HSM800381; Genome Res.11(3), 422-435 (2001).
Bandman et al; “Isolated polynucleotide encoding extracellular matris or adhesion-associated protein (EXMAD) useful for diagnosing, treating, or preventing disorders associated with expression of EXMAD such as proliferative, immune and genetic disorders”, Dayhoff Accession No. P—AAB27228; WO200068380-A2, May 10, 2000; Pub Date Nov. 16, 2000.
Ashkenzai et al; Sixty one nucleic acids encoding PRO polypeptides which are useful in the treatment of skin diseases, cancers and neurodegenerative diseases, Dayhoff Accession No. P—AAB80230; WO200104311-A1, Feb. 22, 2000; Pub Date Jan. 18, 2001.
Botstein, et al; “New antibody that binds to a PRO polypeptide, useful for diagnosing and treating cancers”, Dayhoff Accession No. P—AAB68594; WO200105836-A1, Dec. 20, 1999; Pub Date Jan. 25, 2001.
Goddard et al; “New isolated antibodies which bind to specific polypeptides used for diagnosis and treatment of neoplastic cell growth and proliferation”, Dayhoff Accession No. P—AAY88569; WO200015666-A2, Sep. 8, 1999; Pub Date Mar. 23, 2000.
Ashkenzai et al; “Nucleic acids encoding PRO polypeptides useful for preventing, diagnosing and treating diagnosing a cardiovascular, endothelial or angiogenic disorders in mammals”, Dayhoff Accession No. P—AAB24396; WO200032221-A2, Nov. 30, 1999; Pub Date Jun. 8, 2000.
Botstein et al; “Antibodies against specific proteins overexpressed in tumours”, Dayhoff Accession No. P—AAY05281; WO9914327-A2, Sep. 10, 1998; Pub Date Mar. 25, 1999.
Chen et al; “New isolated human genes and polypeptides used in, e.g. treatment of gastrointestinal ulceration”, Dayhoff Accession No. P—AAY13362; WO9914328-A2, Sep. 16, 1998; Pub Date Mar. 25, 1999.
Pan and Leiby; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAB48106; WO200069885-A2, Dayhoff Accession No. May 15, 2000; Pub Date Nov. 23, 2000.
Pan and Leiby; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, Dayhoff Accession No. P—AAB48135; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Pan and Leiby; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseas

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