Prostaglandins

Details Prostaglandins Prostaglandins

1986-07-22

1989-06-06

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514529, 514530, 514542, 514562, 514564, 514565, 546269, 546305, 546306, 546309, 549463, 560 16, 560 34, 560118, 560120, 562427, 562439, 562500, 562502, 564 17, 564 57, 564180, C07D17700, A61K 31557

Patent

active

048372340

ABSTRACT:
Novel compounds have a formula (I) ##STR1## wherein ##STR2## represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1] heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substituted at the 5-position by the group R.sup.1 and at the 6-position by the group ANR.sup.2 R, a 6,6-dimethyl-bicyclo [3,1,1] heptane substituted at the 2-position by the group R.sup.1 and at the 3-position by the group ANR.sup.2 R or at the 2-position by the group ANR.sup.2 R and at the 3-position by the group R.sup.1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R.sup.1 and at the 5-position by the group ANR.sup.2 R or a 1-hydroxycyclopentane substituted at the 2-position by the group R.sup.1 and at the 2-position by the group ANR.sup.2 R, R.sup.1 is a 6-carboxyhex-2-enyl group or a modification thereof as defined herein; A is an unbranched or branched aliphatic hydrocarbon group with a chain length between the points of attachment to the divalent cyclic group and to the group NR.sup.2 R of 1 to 5 carbon atoms or such a group substituted by an aromatic group; R.sup.2 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups; and R is a group --CO.NR.sup.3 R.sup.4, --CS.NR.sup.3 R.sup.4, --CNH.NR.sup.3 R.sup.4, --CO.R.sup.4 or --CS.R.sup.4 in which R.sup.3 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups, and R.sup.4 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly by an aromatic group or groups and/or through an oxygen or sulphur atom either by an aromatic group or by an aliphatic hydrocarbon group substituted directly by an aromatic group or groups. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

REFERENCES:
patent: 4073933 (1978-02-01), Shimomura
patent: 4416896 (1983-11-01), Nakane
patent: 4418076 (1983-11-01), Nakane
patent: 4456615 (1984-06-01), Nakane
patent: 4463015 (1984-07-01), Haslanger
patent: 4537904 (1985-08-01), Suitman
patent: 4537981 (1985-08-01), Suitman
patent: 4556675 (1985-12-01), Suitman
patent: 4614825 (1986-09-01), Suitman

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