2-aminopyrimidine derivatives and their medical use

Details 2-aminopyrimidine derivatives and their medical use 2-aminopyrimidine derivatives and their medical use

2004-04-08

2009-11-10

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S331000

Reexamination Certificate

active

07615562

ABSTRACT:
A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent.

REFERENCES:
patent: 2007/0270418 (2007-11-01), Ashwell et al.
patent: 96/40143 (1996-12-01), None
patent: 01/12621 (2001-02-01), None
patent: 03/015776 (2003-02-01), None
patent: 03/024971 (2003-03-01), None
Banker et al., Prodrugs, Modern Pharmaceutics, Third Edition, Revised and Expanded, pp. 451 and 596.
Bundgaard, Design of Prodrugs, p. 1, 1985.
Wolff, Some consideration for prodrug design, Burger's Medicinal Chemistry and Drug Discovery, 5th Edition, vol. I: Principles and Practice, pp. 975-977, 1995.

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