Esperamicin derivatives

Details Esperamicin derivatives Esperamicin derivatives

1987-04-29

1989-06-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 168, 536 172, 536 175, 536 176, 536 179, 536 181, 514 61, A61K 3170, C07H 1504

Patent

active

048372064

ABSTRACT:
Novel N-acetyl derivatives designated N-acetyl-esperamicins A.sub.1, A.sub.2 and A.sub.1b are prepared by acetylating known antitumor antibiotics. The new derivatives exhibit both antimicrobial and antitumor activity and have the structures ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or ##STR2## and R.sup.3 is --CH(CH.sub.3).sub.2 or --CH.sub.2 CH.sub.3.

REFERENCES:
patent: 4530835 (1985-06-01), Bunge et al.
patent: 4578271 (1986-03-01), Kiyoto et al.
patent: 4661353 (1987-04-01), Wilton et al.
patent: 4675187 (1987-06-01), Konishi et al.
J. Antibiotics, 38 (11), 1605-1609, 1985.
Cran et al., Organic Chemistry, 2nd Ed., 1969, p. 361.

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