Diagnosis of multiple sclerosis with diketopiperazines

Details Diagnosis of multiple sclerosis with diketopiperazines Diagnosis of multiple sclerosis with diketopiperazines

2003-10-02

2009-08-18

Kolker, Daniel E. (Department: 1649)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

C435S007100

Reexamination Certificate

active

07575929

ABSTRACT:
The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease-associated proteins, such as diketopiperazines composed of the two N-terminal amino acids or the two C-terminal amino acids of such proteins. The methods are useful for diagnosing or monitoring various diseases, including multiple sclerosis, Alzheimer's disease and ischemia. The invention further provides binding partners specific for the markers and compositions and kits for conducting the methods of the invention.

REFERENCES:
patent: 3928330 (1975-12-01), Ramey et al.
patent: 3976773 (1976-08-01), Curran
patent: 4205057 (1980-05-01), Whitaker
patent: 4289759 (1981-09-01), Heavner et al.
patent: 4312987 (1982-01-01), Beck
patent: 4331595 (1982-05-01), Heavner et al.
patent: 4661500 (1987-04-01), Rozencwaig
patent: 4694061 (1987-09-01), Pfeifer
patent: 4694081 (1987-09-01), Miller et al.
patent: 4771056 (1988-09-01), Rozencwaig
patent: 4806538 (1989-02-01), Shimazaki et al.
patent: 4940709 (1990-07-01), Shimazaki et al.
patent: 4992552 (1991-02-01), Hubbs et al.
patent: 5047401 (1991-09-01), Lipsky et al.
patent: 5358938 (1994-10-01), Cai et al.
patent: 5418218 (1995-05-01), Wilber
patent: 5434151 (1995-07-01), Cai et al.
patent: 5463083 (1995-10-01), Biftu et al.
patent: 5512544 (1996-04-01), Wallach et al.
patent: 5538993 (1996-07-01), Mechoulam et al.
patent: 5543402 (1996-08-01), Bosies et al.
patent: 5543503 (1996-08-01), Chuntharapai et al.
patent: 5545404 (1996-08-01), Page
patent: 5550132 (1996-08-01), Benson et al.
patent: 5578323 (1996-11-01), Milstein et al.
patent: 5648486 (1997-07-01), Cai et al.
patent: 5693338 (1997-12-01), Milstein
patent: 5700804 (1997-12-01), Collins et al.
patent: 5703093 (1997-12-01), Cai et al.
patent: 5741809 (1998-04-01), Biftu et al.
patent: 5750530 (1998-05-01), Bryans et al.
patent: 5750565 (1998-05-01), Cai et al.
patent: 5776892 (1998-07-01), Counts et al.
patent: 5780503 (1998-07-01), Biftu et al.
patent: 5792776 (1998-08-01), Biftu et al.
patent: 5817751 (1998-10-01), Szardenings et al.
patent: 5834032 (1998-11-01), Song
patent: 5843950 (1998-12-01), Tasaka et al.
patent: 5856323 (1999-01-01), Cai et al.
patent: 5877174 (1999-03-01), Ono et al.
patent: 5883227 (1999-03-01), Kline et al.
patent: 5886152 (1999-03-01), Nakatani et al.
patent: 5919785 (1999-07-01), Dinsmore et al.
patent: 5932579 (1999-08-01), Campbell et al.
patent: 5976569 (1999-11-01), Milstein
patent: 5985581 (1999-11-01), Nixon et al.
patent: 5990112 (1999-11-01), Campbell et al.
patent: 6034057 (2000-03-01), Dutta
patent: 6034221 (2000-03-01), Berezenko et al.
patent: 6060452 (2000-05-01), Green et al.
patent: 6090780 (2000-07-01), Prasad
patent: 6096737 (2000-08-01), Loder
patent: 6099856 (2000-08-01), Milstein et al.
patent: 6107050 (2000-08-01), Alkon et al.
patent: 6180616 (2001-01-01), Fukunaga
patent: 6222029 (2001-04-01), Edwards et al.
patent: 6248363 (2001-06-01), Patel et al.
patent: 6262119 (2001-07-01), Ferrante et al.
patent: 6265535 (2001-07-01), Greene et al.
patent: 6358957 (2002-03-01), Fukumoto et al.
patent: 6395774 (2002-05-01), Milstein
patent: 6441172 (2002-08-01), Nefzi et al.
patent: 6461875 (2002-10-01), Bar-Or et al.
patent: 6475743 (2002-11-01), Bar-Or et al.
patent: 6492179 (2002-12-01), Bar-Or et al.
patent: 6541224 (2003-04-01), Yu et al.
patent: 6555543 (2003-04-01), Bar-Or et al.
patent: 6635649 (2003-10-01), Teng et al.
patent: 6677473 (2004-01-01), Madison et al.
patent: 6689765 (2004-02-01), Baroudy et al.
patent: 6815214 (2004-11-01), Boyce et al.
patent: 6967202 (2005-11-01), Rao et al.
patent: 7026322 (2006-04-01), Hayashi et al.
patent: 2003/0153575 (2003-08-01), Orme et al.
patent: 2003/0187226 (2003-10-01), Goodey et al.
patent: 2003/0225103 (2003-12-01), Bar-Or et al.
patent: 2004/0038865 (2004-02-01), Gelber et al.
patent: 2004/0132738 (2004-07-01), Teng et al.
patent: 2005/0096323 (2005-05-01), Cheng et al.
patent: 2005/0119177 (2005-06-01), Bar-Or et al.
patent: 2005/0249681 (2005-11-01), Heidenfelder et al.
patent: 254868 (1987-06-01), None
patent: 2827.94 (1996-04-01), None
patent: 2000-2680 (2000-07-01), None
patent: 2000-2681 (2000-07-01), None
patent: 19937721 (2001-02-01), None
patent: 0043219 (1982-01-01), None
patent: 0 214 557 (1987-03-01), None
patent: 0 214 557 (1987-03-01), None
patent: 0216746 (1987-04-01), None
patent: 0493812 (1992-07-01), None
patent: 0557388 (1993-09-01), None
patent: 610943 (1994-08-01), None
patent: 0655060 (1995-05-01), None
patent: 0 835 660 (1998-04-01), None
patent: 939124 (1999-09-01), None
patent: 2717484 (1995-09-01), None
patent: 2263109 (1993-07-01), None
patent: 59-73574 (1984-04-01), None
patent: 63290868 (1988-11-01), None
patent: 01013075 (1989-01-01), None
patent: 3176478 (1991-07-01), None
patent: 08277203 (1996-10-01), None
patent: 10-226615 (1998-08-01), None
patent: 10245315 (1998-09-01), None
patent: 2000327575 (2000-11-01), None
patent: 033544 (2001-08-01), None
patent: 335544 (2001-08-01), None
patent: 2112242 (1998-05-01), None
patent: 2125728 (1999-01-01), None
patent: 2128840 (1999-04-01), None
patent: WO 91/14378 (1991-10-01), None
patent: WO 93/08815 (1993-05-01), None
patent: WO 94/04512 (1994-03-01), None
patent: WO 94/04513 (1994-03-01), None
patent: WO 94/04537 (1994-03-01), None
patent: WO 94/20063 (1994-09-01), None
patent: WO 95/18610 (1995-07-01), None
patent: WO 96/00212 (1996-01-01), None
patent: WO 96/00391 (1996-01-01), None
patent: WO 96/10396 (1996-04-01), None
patent: WO 97/12625 (1997-04-01), None
patent: WO 97/36888 (1997-10-01), None
patent: WO 97/48685 (1997-12-01), None
patent: WO 98/40748 (1998-09-01), None
patent: WO 99/40931 (1999-08-01), None
patent: WO 99/49865 (1999-10-01), None
patent: WO 99/51720 (1999-10-01), None
patent: WO 00/20454 (2000-04-01), None
patent: WO 00/20840 (2000-04-01), None
patent: WO 00/57187 (2000-09-01), None
patent: WO 01/34586 (2001-05-01), None
patent: WO 02/11676 (2002-02-01), None
patent: WO 02/12201 (2002-02-01), None
patent: WO 02/059604 (2002-08-01), None
patent: WO 02/062797 (2002-08-01), None
patent: 2004034060 (2004-04-01), None
patent: 2004/054498 (2004-07-01), None
patent: 2005/011699 (2005-02-01), None
Purves, Dale, et al (Eds.), Neuroscience, 2001, Sinauer Associates, Inc., 2nd Edition, pp. 75, 367, 400, and 403.
Andreasen et al. Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease. Arch. Neurol. Jun;56(6):673-80, 1999.
Michell et al. Biomarkers and Parkinson's Disease. Brain. Aug; 127: 1693-1705, 2004.
Vogel et al. Dissminated tumor cells—Their detection and significance for prognosis of gastrointestianl and pancreatic carcinomas. Virchows Arch 439:109-117, 2001.
Skates et al. Molecular markers for early detection of renal carcinoma: investigative approach. Clin Cancer Res. Sep. 15;10(18 Pt 2):6296S-301S, 2004.
Bunn. Early detection of lung cancer using serum RNA or DNA markers: ready for “prime time” or for validation?J Clin Oncol. Nov. 1;21(21):3891-3, 2003.
Shaw et al. Future of early detection of lung cancer: the role of mouse models.Clin Cancer Res. Jul. 1;11(13 Pt 2):4999s-5003s, 2005.
Bielekova et al. Development of biomarkers in multiple sclerosis. Brain. Jul. 2004;127(Pt 7):1463-78. Epub Jun. 4, 2004.
Rinaldi et al. Immunological markers in multiple sclerosis: tackling the missing elements. Neurol Sci. Dec. 2005;26 Suppl 4:S215-7.
Kuenz et al. Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis. J Neuroimmunol. Oct. 2005;167(1-2):143-9.
Esposito et al., “The Solution Structure of the C-Terminal Segment of Tau Protein,”Journal of Peptide Science2000, 6:550-559.
Gamblin et al., “Tau Polymerization: Role of the Amino Terminus,”Biochemistry2003, 42(7):2252-2257.
Crowe et al., “The N Terminal Region of Human Tau is Present in Alzheimer's Disease Protein A68 and is Inc

Affiliated with

Also associated with

Rating

Diagnosis of multiple sclerosis with diketopiperazines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnosis of multiple sclerosis with diketopiperazines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis of multiple sclerosis with diketopiperazines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4062059