Method for producing optically active bisamidoalcohol compound

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C564S135000, C564S158000, C564S160000

Reexamination Certificate

active

07612236

ABSTRACT:
It is provided that a method for producing an optically active bisamidoalcohol compound represented by the formula (3):wherein R1represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded,R2represents a C1-6 alkyl group, an optionally substituted phenyl group, a 1-naphthyl group, a 2-naphthyl group or an optionally substituted aralkyl group,R3and R4are the same or different, and each represents a hydrogen atom or C1-3 alkyl group,m represents an integer of 0 to 2, and* represents an asymmetric center,which comprises reacting an optically active aminoalcohol compound represented by the formula (1):wherein R1, R2and * are as defined above,with a diester compound represented by the formula (2):wherein R3, R4and m are as defined above and R5represents a C1-3 alkyl group,in the presence of a lithium compound.

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