Fluorescent light tomography

Details Fluorescent light tomography Fluorescent light tomography

2007-04-10

2009-10-06

Le, Long V (Department: 3768)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C600S407000, C600S425000, C600S431000, C600S476000, C250S363010

Reexamination Certificate

active

07599731

ABSTRACT:
Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate—in 3D—the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.

REFERENCES:
patent: 4687325 (1987-08-01), Corby, Jr.
patent: 4687352 (1987-08-01), Igi et al.
patent: 4773097 (1988-09-01), Suzaki et al.
patent: 5202091 (1993-04-01), Lisenbee
patent: 5205291 (1993-04-01), Potter
patent: 5242441 (1993-09-01), Avitall
patent: 5319209 (1994-06-01), Miyakawa et al.
patent: 5334193 (1994-08-01), Nardella
patent: 5414258 (1995-05-01), Liang
patent: 5452723 (1995-09-01), Wu et al.
patent: 5584872 (1996-12-01), LaFontaine et al.
patent: 5594253 (1997-01-01), Bueno et al.
patent: 5636299 (1997-06-01), Bueno et al.
patent: 5637874 (1997-06-01), Honzawa et al.
patent: 5650135 (1997-07-01), Contag et al.
patent: 5661562 (1997-08-01), Aharon
patent: 5672881 (1997-09-01), Striepeke et al.
patent: 5705807 (1998-01-01), Throngnumchai
patent: 5738101 (1998-04-01), Sappey
patent: 5746210 (1998-05-01), Benaron et al.
patent: 5807262 (1998-09-01), Papaioannou et al.
patent: 5812310 (1998-09-01), Stewart et al.
patent: 5818587 (1998-10-01), Devaraj et al.
patent: 5835617 (1998-11-01), Ohta et al.
patent: 5840572 (1998-11-01), Copeland
patent: 5865754 (1999-02-01), Sevick-Muraca et al.
patent: 5867250 (1999-02-01), Baron
patent: 5917190 (1999-06-01), Yodh et al.
patent: 5943129 (1999-08-01), Hoyt et al.
patent: 5953446 (1999-09-01), Opsal et al.
patent: 5963658 (1999-10-01), Klibanov et al.
patent: 5970164 (1999-10-01), Bamberger
patent: 6069698 (2000-05-01), Ozawa et al.
patent: 6108576 (2000-08-01), Alfano et al.
patent: 6175407 (2001-01-01), Sartor
patent: 6205347 (2001-03-01), Morgan et al.
patent: 6208886 (2001-03-01), Alfano et al.
patent: 6217847 (2001-04-01), Contag et al.
patent: 6219566 (2001-04-01), Weersink et al.
patent: 6242743 (2001-06-01), DeVito et al.
patent: 6252623 (2001-06-01), Lu et al.
patent: 6264610 (2001-07-01), Zhu
patent: 6267477 (2001-07-01), Karpol et al.
patent: 6321111 (2001-11-01), Perelman et al.
patent: 6332087 (2001-12-01), Svenson et al.
patent: 6364829 (2002-04-01), Fulghum
patent: 6373557 (2002-04-01), Mengel et al.
patent: 6373568 (2002-04-01), Miller et al.
patent: 6377353 (2002-04-01), Ellis
patent: 6381302 (2002-04-01), Berestov
patent: 6392241 (2002-05-01), Rushbrooke et al.
patent: 6394965 (2002-05-01), Klein
patent: 6403947 (2002-06-01), Hoyt et al.
patent: 6415051 (2002-07-01), Callari et al.
patent: 6429943 (2002-08-01), Opsal et al.
patent: 6529627 (2003-03-01), Callari et al.
patent: 6549288 (2003-04-01), Migdal et al.
patent: 6597931 (2003-07-01), Cheng et al.
patent: 6615061 (2003-09-01), Khalil et al.
patent: 6615063 (2003-09-01), Ntziachristos et al.
patent: 6618152 (2003-09-01), Toida
patent: 6618463 (2003-09-01), Schotland et al.
patent: 6628401 (2003-09-01), Toida
patent: 6628747 (2003-09-01), Schotland et al.
patent: 6636755 (2003-10-01), Toida
patent: 6642953 (2003-11-01), Nieto Velasco et al.
patent: 6646678 (2003-11-01), Kobayashi
patent: 6665072 (2003-12-01), Hoyt
patent: 6690466 (2004-02-01), Miller et al.
patent: 6690520 (2004-02-01), Kusuzawa
patent: 6693710 (2004-02-01), Hoyt
patent: 6710770 (2004-03-01), Tomasi et al.
patent: 6750964 (2004-06-01), Levenson et al.
patent: 6775349 (2004-08-01), Schotland et al.
patent: 6775567 (2004-08-01), Cable
patent: 6813030 (2004-11-01), Tanno
patent: 6919919 (2005-07-01), Nelson et al.
patent: 6924893 (2005-08-01), Oldenbourg et al.
patent: 6963375 (2005-11-01), Lundberg
patent: 7113217 (2006-09-01), Nilson et al.
patent: 7184047 (2007-02-01), Crampton
patent: 7263157 (2007-08-01), Bruder et al.
patent: 2003/0002028 (2003-01-01), Rice et al.
patent: 2003/0099329 (2003-05-01), Schotland et al.
patent: 2004/0010192 (2004-01-01), Benaron et al.
patent: 2004/0015062 (2004-01-01), Ntziachristos et al.
patent: 2004/0021771 (2004-02-01), Stearns et al.
patent: 2004/0027659 (2004-02-01), Messerschmidt et al.
patent: 2004/0085536 (2004-05-01), Schotland et al.
patent: 2004/0262520 (2004-12-01), Schotland et al.
patent: 2005/0149877 (2005-07-01), Rice et al.
patent: 2005/0283071 (2005-12-01), Ripoll et al.
patent: 2006/0118742 (2006-06-01), Levenson et al.
patent: 2006/0119865 (2006-06-01), Hoyt et al.
patent: 2006/0146346 (2006-07-01), Hoyt
patent: 2006/0173354 (2006-08-01), Ntziachristos et al.
patent: 2006/0203244 (2006-09-01), Nilson et al.
patent: 2006/0245631 (2006-11-01), Levenson et al.
patent: 2006/0268153 (2006-11-01), Rice et al.
patent: 2007/0016078 (2007-01-01), Hoyt et al.
patent: 1 016 419 (2000-07-01), None
patent: 06-129984 (1994-05-01), None
patent: 08-136448 (1996-05-01), None
patent: 09-504964 (1997-05-01), None
patent: 10-510626 (1998-10-01), None
patent: 11-173976 (1999-07-01), None
patent: 2000-500228 (2000-01-01), None
patent: 2002-511778 (2002-04-01), None
patent: 96/16596 (1996-06-01), None
patent: WO97/40381 (1997-10-01), None
patent: WO98/34533 (1998-08-01), None
patent: WO 00/17643 (2000-03-01), None
patent: WO00/36106 (2000-06-01), None
patent: WO00/54581 (2000-09-01), None
patent: WO01/18225 (2001-03-01), None
patent: WO01/63247 (2001-08-01), None
patent: WOO2/41760 (2002-05-01), None
EP Search Report dated Oct. 6, 2006 for EP Application No. EP 06 01 3492.
Australian Office Action dated Jul. 25, 2006 for Australian Application No. 2002303819.
Pickering et al., “Double-integrating-sphere system for measuring the optical properties of tissue,” Applied Optics, Feb. 1, 1993, vol. 32, No. 4, pp. 399-410.
Benaron, David A., “A System for Imaging Infection and Gene Expression in the Body in 3-D,” Biomedical Optical Spectroscopy amd Diagnostics, 1998 Technical Digest, 1998, Optical Society of America, pp. 134-135.
Frohn, “Super-Resolution Fluorescence Microscopy by Structured Light Illumination,” Dissertatiom submitted to the Swiss Federal Institute of Technology, Zurich, 2000.
Rice et al., “Advances in 2D In Vivo Optical Imaging Instrumentation,” Abstract No. 186, Society for Molecular Imaging 2ndAnnual Meeting, Aug. 2003.
Achilefu et al., “Novel Receptor-Targeted Fluorescent Contrast Agents for In Vivo Tumor Imaging”, Investigative Radiology, vol. 35(8), Aug. 200, pp. 479-485.
Arridge, “Photon-Measurement Density Functions. Part 1: Analytical Forms”, Applied Optics, vol. 34, No. 31, Nov. 1, 1995, pp. 7395-7409.
Arridge, “Photon-Measurement Density Functions. Part 2: Finite-Element-Method Calculations”, Applied Optics, vol. 34, No. 34, Dec. 1, 1995, pp. 8026-8037.
Becker et al., “receptor-Targeted Optical Imaging of Tumors with Near-Infrared Fluorescent Ligands”, Nature Biotechnology, vol. 19, Apr. 2001, pp. 327-330.
Bevilacqua et al., “In Vivo Local Determination of Tissue Optical Properties: Applications to Human Brain”, Applied Optics, vol. 38, No. 22, Aug. 1, 1999, pp. 4939-4950.
Bevilacqua et al., “Monte Carlo Study of Diffuse Reflectance at Source-Detector Separations Close to One Transport Mean Free Path”, Optical Society of America, vol. 16, No. 12, Dec. 1999, pp. 2935-2945.
Bouvet et al., “Real-Time Optical Imaging of Primary Tumor Growth and Multiple Metastatic Events in a Pancreatic Cancer Orthotopic Model”, Cancer Research, vol. 62, Mar. 1, 2002, pp. 1534-1540.
Chang et al., “Improved Reconstruction Algorithm for Luminescence Optical Tomography When Background Lumiphore is Present”, Applied Optics, vol. 37, No. 16, Jun. 1, 1998, pp. 3547-3552.
Cheong et al., “A review of the Optical Properties of Biological Tissues”, IEEE Journal of Quantum Electronics, vol. 26, No. 12,

Affiliated with

Also associated with

Rating

Fluorescent light tomography does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorescent light tomography, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorescent light tomography will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4056858