Pyrido[2,3-D]pyrimidine inhibitors of phosphodiesterase (PDE) 7

Details Pyrido[2,3-D]pyrimidine inhibitors of phosphodiesterase (PDE) 7 Pyrido[2,3-D]pyrimidine inhibitors of phosphodiesterase (PDE) 7

2005-11-17

2009-10-13

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C548S190000

Reexamination Certificate

active

07601836

ABSTRACT:
Pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors are provided which are useful in treating T-cell mediated diseases, said inhibitors include:(i) 2-[[4-[[[4-(Aminosulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester; and4-Methyl-2-[[4-[[[4-(methylsulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-5-thiazolecarboxylic acid, ethyl ester; or(ii) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt of (i).

REFERENCES:
patent: 5439895 (1995-08-01), Lee et al.
patent: 5693652 (1997-12-01), Takase et al.
patent: 5739127 (1998-04-01), Schohe-Loop et al.
patent: 5801180 (1998-09-01), Takase et al.
patent: 5874438 (1999-02-01), Schohe-Loop et al.
patent: 6200976 (2001-03-01), Ries et al.
patent: 6339089 (2002-01-01), Nakashima et al.
patent: 2009145 (1989-09-01), None
patent: 664262 (1952-01-01), None
patent: WO 92/07844 (1992-05-01), None
patent: WO 97/20821 (1997-06-01), None
patent: WO 97/20822 (1997-06-01), None
patent: WO 98/13350 (1998-04-01), None
patent: WO 98/56376 (1998-12-01), None
patent: WO 99/40089 (1999-08-01), None
patent: WO 01/055147 (2001-08-01), None
patent: WO 01/55148 (2001-08-01), None
patent: WO 01/68615 (2001-09-01), None
patent: WO 02/24666 (2002-03-01), None
patent: WO 02/24667 (2002-03-01), None
patent: WO 02/30358 (2002-04-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, p. 205.
DörwaId, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2005, Preface.
Patani, et al. Chem. Rev., 96, 1996, pp. 3147-3176.
Elslager et al., J. Med. Chem., 24:127-140 (1981).
Nakata A. et al., Clin. Exp. Immunol, 2002, vol. 128, pp. 460-466.

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