Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2004-10-18
2009-12-15
Lu, Frank W (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S006120, C435S007100, C435S287200, C422S068100
Reexamination Certificate
active
07632671
ABSTRACT:
The presence of a nucleic acid target, molecule or ligand can be detected by hybridization, antigen-antibody reaction or receptor-ligand binding. This is reported by the strategic positioning of a first probe and a second probe attached to a small particle of electrical conductor, which closes an electrical circuit, thereby reporting the event. A myriad of potential applications of this technique include the identification and detection of small amounts of nucleic acids by hybridization, the detection of molecules such as toxins and carcinogens by antigen-antibody reaction and the detection of other molecules by receptor-ligand interaction. The method can also be adapted to assay the quantity of a given substance using the principle of competitive binding.
REFERENCES:
patent: 4321057 (1982-03-01), Buckles
patent: 5385707 (1995-01-01), Miltenyi et al.
patent: 5391272 (1995-02-01), Daly et al.
patent: 5966813 (1999-10-01), Durand
patent: 5981921 (1999-11-01), Yablochnikov
patent: 6104012 (2000-08-01), Durand
patent: 6234375 (2001-05-01), Durand
patent: 6569647 (2003-05-01), Zhang et al.
patent: 6828432 (2004-12-01), Mirkin et al.
patent: 2003/0207296 (2003-11-01), Park et al.
patent: 2003/0215825 (2003-11-01), Tong
patent: 371714 (1999-10-01), None
patent: WO95/15496 (1995-06-01), None
Häarmä, Harri. “Particle technologies in diagnostics”, Technology Review, vol. 126, pp. 1-30 (2002).
Baselt et al., “A biosensor based on Magnetoresistance technology”, vol. 13, pp. 731-739 (1998).
Robert F. Service, “New Test Could Speed Bioweapon Detection” Science, vol. 295, p. 1447 (2002).
Jaw-Min Nam et al., “Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins”, Science, vol. 301, pp. 1884-1886 (2003).
Park, S-J, Taton, T.A, and Mirkin, C.A.. Array-Based Electrical Detection of DNA With Nanoparticle Probes, Science, vol. 295, Feb. 22, 2002.
Baselt, et al., “A biosensor based on magnetoresistance technology,” Biosensors & Bioelectronics, vol. 13, p. 731-739 (1998).
Härmä, Harri, “Particle technologies in diagnostics,” Technology Review, vol. 126 (2002).
U.S. Office Action for Tong Sun Wing, U.S. Appl. No. 09/997,059, filed Nov. 29, 2001, dated Jul. 17, 2003.
U.S. Office Action for Tong Sun Wing, U.S. Appl. No. 09/997,059, filed Nov. 29, 2001, dated Nov. 13, 2003.
Law Offices of Albert Wai-Kit Chan PLLC
Lu Frank W
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