Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-10-24
2008-11-11
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07449295
ABSTRACT:
Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
REFERENCES:
patent: 1591534 (2005-11-01), None
patent: WO 03034029 (2003-04-01), None
patent: WO-2005095650 (2005-10-01), None
Beiboer, Sigrid H.W., et al., “Rapid Genotyping of Blood Group Antigens by Multiplex Polymerase Chain Reaction and DNA Microarray Hybridization,”Transfusion45: 667-679 (May 2005).
PCT Search Report PCT/US05/38296 (2006).
S.W. Beiboer et al. “Rapid Genotyping of Blood Group Antigens by Multiplex Polymerase Chain Reaction and DNA Microarray Hybridization” 45 Transfusion 667-679 (2005).
M.E. Reid et al. “Novel Dombrock Blood Group Genetic Variants . . . ” Blood (ASH Annual Meeting Abstracts) 2004, 104:Abstract 383.
M. St-Loius et al. “Extended Blood Grouping of Blood Donors . . . ” Transfusion 43: 1126-1132 (2003).
M.E. Reid “The Dombrock Blood Group System: a Review” Transfusion 43: 107-114 (2003).
Y.X. Chen et al. “Deletion of Arginine Codon 229 . . . ” Transfusion 44: 391-398 (2004).
E. Strobel et al. “The molecular basis of Rhesus antigen E” Transfusion 44: 407-09 (2004).
Hashmi Ghazala
Pierce Michael
Reid Marion E.
Seul Michael
Bio Array Solutions
Martinell James
Mirabel Eric P.
New York Blood Center
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