Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2002-09-05
2008-11-04
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S336000, C514S343000, C544S364000, C546S276400, C546S283400
Reexamination Certificate
active
07446106
ABSTRACT:
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
REFERENCES:
patent: 5776954 (1998-07-01), De Laszlo et al.
patent: 5837719 (1998-11-01), de Laszlo et al.
patent: 7135550 (2006-11-01), Come et al.
patent: 2 306 108 (1997-04-01), None
patent: 2001181187 (2001-03-01), None
patent: WO 97/05878 (1997-02-01), None
patent: WO 97/16441 (1997-05-01), None
patent: WO 97/16442 (1997-05-01), None
patent: WO 97/36587 (1997-10-01), None
patent: WO 99/25717 (1999-05-01), None
patent: WO 00/01688 (2000-01-01), None
patent: WO 01/66539 (2000-09-01), None
patent: WO 00/64422 (2000-11-01), None
patent: WO 00/66124 (2000-11-01), None
patent: WO 00/69847 (2000-11-01), None
patent: WO 01/38324 (2001-05-01), None
patent: WO 01/66540 (2001-09-01), None
patent: WO 02/24680 (2002-03-01), None
patent: WO 02/057255 (2002-07-01), None
Revesz et al., SAR of 4-Hydroxypiperidine and Hydroxyalkyl Substituted Heterocycles as Novel p38 Map Kinase Inhibitors, Biorganic & Chemistry Letters, 10, pp. 1261-1264, 2000.
Lisnock et al., CAPLUS Abstract 130:308306, 1999.
Katritzky et al., CAPLUS Abstract 124:145994, 1995.
Kankare et al., CAPLUS Abstract 122:80507, 1995.
Katritzky et al., CAPLUS Abstract 113:153394, 1990.
Bhattacharjee et al., CAPLUS Abstract 94:65598, 1981.
Giridhar et al., CAPLUS Abstract 74:99815, 1971.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Keller et al., The role of Raf Kinase inhibitor protein (RKIP) in health and disease, Biochemical Pharmacology, 68, pp. 1049-1053, 2004.
Traxler, Protein Tyrosine Kinase inhibitors in cancer treatment, Exp. Opin. Ther. Patents, 7(6):571-588, 1997.
Layzer, Degenerative diseases of the nervous system, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 2050-2057, 1996.
Damasio, Alzheimer's Disease and related dementias, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1992-1996, 1996.
De Laszlo et al., “Pyrroles and other heterocycles as inhibitors of p38 kinase”, Biorg. Med. Chem. Lett., vol. 8, 1998, pp. 2689-2694.
De Laszlo et al., “Potent, orally absorbed glucagon receptor antagonists”, Biorg. Med. Chem. Lett, vol. 9, 1999, pp. 641-646.
Liveton et al., “Design and Synthesis of Potent, Selective and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase”, J. Med. Chem., vol. 42, No. 12, 1999, pp. 2180-2190.
Kalmes et al., Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580, Febs Letters, vol. 444, No. 1, 1999, pp. 71-74.
Lisnock et al., “Molecular Basis for p38 Protein Kinase Specifity”, Biochemistry, vo. 37, No. 47, 1998, pp. 16573-16581.
Cascieri et al., “Characterization of a Novel, Non-peptidyl Antagonist of the Human Glucagon Receptor”, J. Biol. Chem., vol. 274, No. 13, 1999, pp. 8694-8697.
Dean David Kenneth
Takle Andrew Kenneth
Wilson David Matthew
Hsu Grace C.
Kinzig Charles M.
McCarthy Mary E.
Rao Deepak
SmithKline Beecham plc
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