Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2003-06-28
2008-11-25
Romeo, David (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387900, C530S387700, C530S388240, C530S388800, C424S130100, C424S133100, C424S141100, C424S138100, C424S152100, C424S158100
Reexamination Certificate
active
07456262
ABSTRACT:
Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of IIAS2, IIA, CD44 or RIIAMM by native human WISP-1 polypeptide in at least one type of cells or pathological conditions associated with native WISP-1 polypeptides.
REFERENCES:
patent: WO 99/21998 (1999-05-01), None
patent: WO 01/53486 (2001-07-01), None
patent: WO 2004/003158 (2004-01-01), None
patent: WO 2005/025603 (2005-03-01), None
Pennica D, et al., “WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors”Proc. Natl. Acad. Sci. USA95(25):14717-14722 (Dec. 8, 1998).
Xu et al., “WISP-1 is a Wnt-1- and β-catenin-responsive oncogene”Gene&Develop. 14:585-595 (2000).
Saxena , N. et al., “Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines”Mol. Cell. Biochem. 228:99-104 (2001).
Xie, D. et al., “Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features”Cancer Research61:8917-8923 (2001).
Desnoyers et al., “WISP-1 Binds to Decorin and Biglycan”Journal of Biological Chemistry276:47599-47607 (2001).
Soon et al., “Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation”J. Biol. Chemistry278(13):11465-11470 (2003).
Desnoyers Luc
Filvaroff Ellen
Gamett Daniel C
Genentech Inc.
Romeo David
Ropp Traci H.
LandOfFree
Methods and composition for modulating and detecting wisp... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and composition for modulating and detecting wisp..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and composition for modulating and detecting wisp... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4037907