Polydiazeniumdiolated cyclic polyamines with polyphasic...

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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Reexamination Certificate

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07468435

ABSTRACT:
The present invention provides compound of the formula (I):in which at least two of R1, R2, R3, R4, R5, and R6are N2O2M and related compounds substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.

REFERENCES:
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5250550 (1993-10-01), Keefer et al.
patent: 5366997 (1994-11-01), Keefer et al.
patent: 5587451 (1996-12-01), Athey et al.
patent: 5650447 (1997-07-01), Keefer et al.
patent: 5721365 (1998-02-01), Keefer et al.
patent: 5731305 (1998-03-01), Keefer et al.
patent: 5910316 (1999-06-01), Keefer et al.
patent: 2005/0148566 (2005-07-01), Waterhouse et al.
patent: WO 98/13358 (1998-04-01), None
patent: WO 01/92215 (2001-12-01), None
Wayland et al. Journal of the Chemical Society, Chemical Communications, 1976, 24, 1015-1016.
Tamara et al. Tanpakushitsu Kakusan Koso, Bessatsu, 1976, 76(5), 225-40. (based on HCAPlus record).
Atkins et al., “Macrocyclic Polyamines: 1,4,7,10,13,16-Hexaäzacycloöctadecane”Organic Synthesis, Collective vol. VI, 652-661 (1988).
Barefield et al., “Synthesis of Macrocyclic Tetramines by Metal Ion Assisted Cyclization Reactions”Inorg. Chem., 15 (6), 1370-1377 (1976).
Bellouard et al., “cis-Diprotected Cyclams and Cyclens: a New Route to Symmetrically or Asymmetrically 1,4-Disubstituted Tetraazamacrocycles and to Asymmetrically Tetrasubstituted Derivatives”J. Chem. Soc., Perkin Trans. 1, 3499-3505 (1999).
Boldrini et al., “ExpeditiousN-Monoalkylation of 1,4,7,10-Tetraazacyclododecane (cyclen)via Formamido Protection”Tetrahedron Letters, 41, 6527-6530 (2000).
Drago et al., “The Reaction of Nitrogen(II) Oxide with Various Primary and Secondary Amines”J. Am. Chem. Soc., 83, 1819-1822 (Apr. 20, 1961).
Hrabie et al., “New Nitric Oxide-Releasing Zwitterions Derived from Polyamines”J. Org. Chem., 58, 1472-1476 (1993).
Hrabie et al., “Adducts of Piperazine with Nitric Oxide”Org. Prep. and Proc. Int., 31 (2), 189-192 (1999).
Kovacs et al., “pH Controlled Selective Protection of Polyaza Macrocycles”Synthesis, 759-763 (Jul. 1997).
Longhi et al., “Reactions of Nitrogen (II) Oxide with Miscellaneous Lewis Bases”Inorg. Chem., 1 (4). 768-770 (Nov. 1962).
Meunier et al., “Synthesis and Characterization of Various Unsubstituted and Mono-N-Substituted Tetraazamacrocycles”Can. J. Chem., 73, 685-695 (1995).
Militsopoulou et al., “Simple Synthesis of Cyclic Polyamines Using Selectively N-Tritylated Polyamines and Succinic Anhydride”Tetrahedron Letters, 43, 2593-2596 (2002).
Panetta et al., “Triflamides for Protection and Cyclization of Tetraamines to Tetraazamacrocycles”Tetrahedron Letters, 33 (38), 5505-5508 (1992).
Reed et al.,Organic Synthesis, 78, 73-81 (2000).
Yang et al., “Facile N-1 Protection of Cyclam, Cyclen and 1,4,7-Triazacyclononane”Tetrahedron Letters, 44, 2481-2483 (2003).

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